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NEUROENDOKRINI (Neuroendocrine tumors (NETs) carcinoid (NETs usually…
NEUROENDOKRINI
Neuroendocrine tumors (NETs) carcinoid
Site:
GIT (majority)
Appendix (most common)
small intestine (esp. ileum)>
rectum>
stomach>
colon, pancreas and biliary tree
Tracheobronchial tree and lung
NETs usually behave according to their
Site:
Midgut
foregut
Hindgut
(i.e. appendix rarely Mets.)
Depth of local penetration.
Size of the tumor: > 2 cm
Grossly:
Solid yellow - tan submucosal
mass
Under the Microscope:
Islands, trabeculae, glands (that's
why it's important to differentiate it
from adenocarcinoma)
sheets of
uniform cells with scant, cytoplasm
and a round stippled nucleus
All NETs are potentially malignant tumors
Origin:
Neuroendocrine cells
Clinical correlations
asymptomatic.
Rarely produce local symptoms
(due to angulation or obstruction of small
intestine)
The secretory products of some carcinoids can produce a variety of syndromes
or endocrinopathies
→ e.g. CARCINOID SYNDROME
baza
https://www.youtube.com/watch?v=_A6GbgUnEZc
Karcinoid tumor
https://www.youtube.com/watch?v=AFCLUyDhwAw
Th
modeli
sveobuhvatno
baza
https://www.youtube.com/watch?v=QOKINFpNGtY
7 studija
RADIANT, 3, 4
https://www.youtube.com/watch?v=VrS6akzR3sk
https://www.youtube.com/watch?v=fa549RILAWo
PROMID, CLARINET
https://www.youtube.com/watch?v=zz8AuolJwfI
NETTER
https://www.youtube.com/watch?v=qEV_RJCD20o
SUNITINIB
TELESTAR
https://www.youtube.com/watch?v=GfCqMv--ncA
master
http://www.primeoncology.org/online-education/solid-tumor/masterclass-nets-amsterdam-2017-slides/
kemoth
Coggle
https://coggle.it/diagram/WMf1j_RAHgABHVVN/t/gastroenteropankreatische-neuroendokrine-gep-net
oštećenje srca
https://www.google.ba/search?q=carcinoid+heart+valve+pathophysiology&source=lnms&tbm=isch&sa=X&ved=0ahUKEwiU6pmrtdzaAhWFDpoKHYCXBPEQ_AUICigB&biw=1229&bih=548#imgrc=_n75YvkN0PIv4M
:
Case
studije
Patology
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5093292/
pismo uredniku
https://sci-hub.tw/10.4103/0970-9371.80755
Onkologist
http://theoncologist.alphamedpress.org/content/21/1/28.full.pdf+html