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Metastatic, LAD (Th (Hormonska (studije, FASLODEX (CONFIRM (https://www…
Metastatic, LAD
Th
HER poz
TDM1
studije
EMILIA
https://www.youtube.com/watch?v=E3jypO7t5tI
http://www.nejm.org/doi/full/10.1056/NEJMoa1209124
THERESA
https://www.youtube.com/watch?v=4yRk91_5jS4
https://www.ncbi.nlm.nih.gov/pubmed/24793816
MARIANA
https://www.youtube.com/watch?v=kbYqb0I1Wnc
https://www.ncbi.nlm.nih.gov/pubmed/28056202
Trastuzumab
linije
1 L
Denis Slamon
https://www.youtube.com/watch?v=6q5Qt-BSm8Q
http://www.nejm.org/doi/full/10.1056/NEJM200103153441101
HERNATA
https://www.youtube.com/watch?v=x4j8F1dMA_0
https://www.ncbi.nlm.nih.gov/pubmed/21149659
CLEOPATRA
https://www.youtube.com/watch?v=DWTFXG1yEJ4
https://www.google.ba/search?q=cleopatra+study+breast&source=lnms&tbm=isch&sa=X&ved=0ahUKEwjyvb6AwcbZAhUDr6QKHWLUBzIQ_AUICigB&biw=1229&bih=607#imgrc=qsoGyONdG3JVLM
:
808 pts, Tr+Doc vs Tras+Doc+Per, PFS 18vs12, OS 65.7 vs 40.4 mj, HR 0.67
https://www.nejm.org/doi/full/10.1056/NEJMoa1413513
M31
https://www.google.ba/search?q=MA+31+study&source=lnms&tbm=isch&sa=X&ved=0ahUKEwi2_autwMbZAhXOyaQKHc9PDgcQ_AUICigB&biw=1229&bih=607#imgrc=ZHXXbTERcHzzdM
:
BOLERO 1
https://www.youtube.com/watch?v=7-1RAU9HLQc
https://www.google.ba/search?q=bolero+1+trial&source=lnms&tbm=isch&sa=X&ved=0ahUKEwiTse27v8bZAhXI2aQKHaGaD_YQ_AUICigB&biw=1229&bih=607#imgrc=Q_SG7FD8gI0UaM
:
1L, eve+trast+taxol, PFS 15mjvs15mj, HR- 20vs13 mjss
https://www.thelancet.com/journals/lanonc/article/PIIS1470-2045(15)00051-0/abstract?code=lancet-site
2 L
lapatinib
2L
Geyer
1 more item...
Lap+Tras, EFG104900
https://www.youtube.com/watch?v=3V6oF9rIdZA
https://www.youtube.com/watch?v=Qsm0wOmgIuw
https://www.ncbi.nlm.nih.gov/pubmed/22689807
EMILIA
https://www.youtube.com/watch?v=BPBQ22lROR4
http://www.nejm.org/doi/full/10.1056/NEJMoa1209124
von Minkwitz
https://www.youtube.com/watch?v=qRuAXKmB0No
https://www.ncbi.nlm.nih.gov/pubmed/19289619
BOLERO
BOLERO 3
https://www.youtube.com/watch?v=EMefIe8TDyY
http://www.thelancet.com/journals/lanonc/article/PIIS1470-2045(14)70138-X/abstract
evr+her+vino, pfs 7vs6mj, hr0.80
prethodno L i Tras
Theresa
https://www.youtube.com/watch?v=scEPo4arHDI
https://www.ncbi.nlm.nih.gov/pubmed/24793816
drugi agenti
Vino
VELVET
https://breast-cancer-research.biomedcentral.com/articles/10.1186/s13058-016-0773-6
kape
PHEREXA
https://www.youtube.com/watch?v=DOJ48DrFews
http://ascopubs.org/doi/abs/10.1200/JCO.2016.70.6267?journalCode=jco
taxani drugi
PERUSE
https://www.youtube.com/watch?v=FpxrpZ2AK7E
http://www.esmo.org/Conferences/Past-Conferences/European-Cancer-Congress-2015/News/Preliminary-Results-from-PERUSE-Study-Increase-Treatment-Options-in-HER-Positive-Patients-with-Metastatic-Breast-Cancer
HT
studije
https://www.google.ba/search?biw=1229&bih=607&tbm=isch&sa=1&ei=5IuVWpf4B4uXkwX0z6mwDQ&q=herceptin+metastatic+study&oq=herceptin+metastatic+study&gs_l=psy-ab.3...4487.7193.0.7452.6.6.0.0.0.0.177.779.0j6.6.0....0...1c.1.64.psy-ab..0.0.0....0.uQxtf1ZOb3E#imgrc=uth_YKsgffsSYM
:
https://www.youtube.com/watch?v=Ak29UqCHx-M
https://www.youtube.com/watch?v=D2monVkCkX4
https://www.youtube.com/watch?v=zLSQKephgmU
PERTAIN
https://clinicaltrials.gov/ct2/show/NCT01491737
VEGFR
Bevacizumab
E2100
http://www.nejm.org/doi/full/10.1056/NEJMoa072113
https://www.google.ba/search?q=e2100+bevacizumab&source=lnms&tbm=isch&sa=X&ved=0ahUKEwjC8Zfrs-naAhUByqYKHQMNBUoQ_AUICigB&biw=1229&bih=587#imgrc=IoL9_IEkFpZJzM
:
AVADO
http://ascopubs.org/doi/full/10.1200/jco.2008.21.6457
https://www.youtube.com/watch?v=XTJIGGBN8l4
RIBON
1 L
https://www.ncbi.nlm.nih.gov/pubmed/21383283
2 L
https://www.ncbi.nlm.nih.gov/pubmed/21990397
https://www.google.ba/search?q=ribbon+2+study&source=lnms&tbm=isch&sa=X&ved=0ahUKEwjpq6jEtOnaAhVjOpoKHcdfCnoQ_AUICigB&biw=1229&bih=587#imgrc=GaB0HbyoGofKkM
:
https://www.youtube.com/watch?v=WiyGwkEzSto
studije zbirno
https://www.google.ba/search?biw=1229&bih=607&tbm=isch&sa=1&ei=nouVWoHsE8zVkwWmnr7oBQ&q=difference+between+e2100+vs+ribbon+study&oq=difference+between+e2100+vs+ribbon+study&gs_l=psy-ab.3...10052.11211.0.11519.2.2.0.0.0.0.102.194.1j1.2.0....0...1c.1.64.psy-ab..0.0.0....0.1wxA7W2XFEw#imgrc=Z92SwERrOROJZM
:
https://www.google.ba/search?q=ribbon+1+study&source=lnms&tbm=isch&sa=X&ved=0ahUKEwiN9c-FtOnaAhWjw6YKHZ-8BM8Q_AUICigB&biw=1229&bih=587#imgrc=cvdAGv6NKHDlEM
:
TANIA
https://www.ncbi.nlm.nih.gov/pubmed/27502725
https://www.youtube.com/watch?v=iAEh19lXPSc
Bevacizumab+hormonska
LEA
https://www.google.ba/search?q=bevacizumab+adjuvant+therapy+breast&source=lnms&tbm=isch&sa=X&ved=0ahUKEwjMnOXw1unaAhUDMZoKHfXEB7EQ_AUICigB&biw=1229&bih=548#imgrc=6p4GNIbLOjtRWM
:
TURANDOT
https://www.ncbi.nlm.nih.gov/pubmed/27501767
RT
SBRT
NRG BR 002
https://www.youtube.com/watch?v=Qbn2XCV6txI
COMET
https://www.youtube.com/watch?v=fGTq14qCwJk
SBRT
TN
kemoth
Etirinotekan (TIRIĆ TEKA)
BEACON
https://www.youtube.com/watch?v=_tvx_CKB7uI
http://www.thelancet.com/journals/lanonc/article/PIIS1470-2045(15)00332-0/abstract
Eribulin
EMBRACE
http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(11)60070-6/abstract
Ixabeipolon
https://www.youtube.com/watch?v=Qnb2ZdoxbbU
RR12%
https://www.cancer.gov/about-cancer/treatment/drugs/fda-ixabepilone
novi klinci
sacituzumab govitecan
https://www.youtube.com/watch?v=I9POwXSSOEk
meta
Trop 2
https://www.youtube.com/watch?v=_V_nZNWPYQk
pik/AKT/mtor inhibitor
LOTUS (Akt inhibitor)
https://www.youtube.com/watch?v=z9CJ6mkRb0I
https://www.ncbi.nlm.nih.gov/pubmed/28800861
Ipata+Taxolvs taxol, poz PFS, + trend 32vs18 mj
IPATASERIB-AKT inhibitor (PIK-mTOR-PTEn
https://www.youtube.com/watch?v=7itg5SGYLe0
PAKT
Glembatumumab
https://www.youtube.com/watch?v=Te47BDdb5eI
studija
EMERGE
https://www.youtube.com/watch?v=rEqbvSX3Bus
neg, veći RR povećan glikoprotein
MOA: glikoprotein
https://www.youtube.com/watch?v=DsebjG15HNM
TOPACIO
f2, 55pts, 2L kt, ORR 30%(3CR)
MOA: aktivacija STING-stimulacija interferona koji aktivira INt y za akumulaciju tm stanica
https://www.youtube.com/watch?v=QK-Z1K67uaA
PARP+Pembro
Ladiratuzumab vedotin
TN
terapije po subgrupama
https://www.google.ba/search?biw=1229&bih=548&tbm=isch&sa=1&ei=cTLrWq7pK-vB6AS395_IDw&q=triple+negative+breast+cancer+therapy+subrgrup&oq=triple+negative+breast+cancer+therapy+subrgrup&gs_l=psy-ab.3...1481.9019.0.9306.30.20.0.10.10.0.347.2445.2j9j3j1.15.0....0...1c.1.64.psy-ab..6.14.904...0i19k1j0i24k1.0.QlZDkQUJ4pY#imgrc=rh3YR2CBi2GcuM
:
po lokaciji
https://www.youtube.com/watch?v=jHxyP-nUhUY
Lokalna
https://www.youtube.com/watch?v=jHxyP-nUhUY
GPA (Graded Prognostic Assessment )
https://www.youtube.com/watch?v=F9tni2Z-T0w
Japansska studija 99-1
https://www.youtube.com/watch?v=Atyd84SGnBM
EORTC
https://www.youtube.com/watch?v=O37yJBFRrfg
Columbia univerzitet
https://www.youtube.com/watch?v=uAovPpfK_DA
Lokalna
https://www.google.ba/search?biw=1229&bih=607&tbm=isch&sa=1&ei=jZCVWtTrNoWSsAf1wJ6gBw&q=wbrtmetastatic++brain+study&oq=wbrtmetastatic++brain+study&gs_l=psy-ab.3...4872.7422.0.7880.11.11.0.0.0.0.133.1286.1j10.11.0....0...1c.1.64.psy-ab..0.0.0....0.eUaODErMeq0#imgrc=4geqlo_btw1xRM
:
Sistemska
Tem
cis, 18% RR
kap, RR 40%
Lapatinib
LAPTEM
https://www.youtube.com/watch?v=k_GM1JA608Y
https://www.ncbi.nlm.nih.gov/pubmed/24013582
LANDSCAPE
https://www.youtube.com/watch?v=fCBusmHtFuU
https://www.ncbi.nlm.nih.gov/pubmed/23122784
HER poz
Neratinib
https://www.youtube.com/watch?v=YGF05vzbvwg
ONT 380
https://www.youtube.com/watch?v=1Ntoml52-K0
studije zbir
https://www.google.ba/search?biw=1229&bih=607&tbm=isch&sa=1&ei=jZCVWtTrNoWSsAf1wJ6gBw&q=chemotherapy+breast+brain+metastasis&oq=chemotherapy+breast+brain+metastasis&gs_l=psy-ab.3...2635.19904.0.20703.52.51.0.0.0.0.199.5306.10j38.48.0....0...1c.1.64.psy-ab..6.2.272...0i19k1j0i7i30i19k1j0i7i30k1j0i8i7i30k1.0.p64NYcBuajI#imgrc=PzGRZ337DzndlM
:
https://www.google.ba/search?biw=1229&bih=607&tbm=isch&sa=1&ei=jZCVWtTrNoWSsAf1wJ6gBw&q=chemotherapy+breast+brain+metastasis&oq=chemotherapy+breast+brain+metastasis&gs_l=psy-ab.3...2635.19904.0.20703.52.51.0.0.0.0.199.5306.10j38.48.0....0...1c.1.64.psy-ab..6.2.272...0i19k1j0i7i30i19k1j0i7i30k1j0i8i7i30k1.0.p64NYcBuajI#imgrc=bOBYa5xWVs7_EM
:
nalaz
https://www.google.ba/search?biw=1229&bih=607&tbm=isch&sa=1&ei=jZCVWtTrNoWSsAf1wJ6gBw&q=chemotherapy+breast+brain+metastasis&oq=chemotherapy+breast+brain+metastasis&gs_l=psy-ab.3...2635.19904.0.20703.52.51.0.0.0.0.199.5306.10j38.48.0....0...1c.1.64.psy-ab..6.2.272...0i19k1j0i7i30i19k1j0i7i30k1j0i8i7i30k1.0.p64NYcBuajI#imgrc=-m4Ny6-PY-I6yM
:
cis+Eto, 40%RR
Hormonska
studije, FASLODEX
FACT
https://www.google.ba/search?q=S0226+study&source=lnms&tbm=isch&sa=X&ved=0ahUKEwjj9oLGycbZAhUB_aQKHYOvBBEQ_AUICigB&biw=1229&bih=607#imgrc=bQgvjDsroi7agM
:
S0226
https://www.youtube.com/watch?v=9DwE3MFVUVI
https://www.ncbi.nlm.nih.gov/pubmed/22853014
CONFIRM
https://www.google.ba/search?biw=1229&bih=607&tbm=isch&sa=1&ei=EZCVWp_IOMLQkwWOqoZg&q=cofirm+study+falodex+breast&oq=cofirm+study+falodex+breast&gs_l=psy-ab.3...5750.15813.0.16060.33.30.3.0.0.0.160.3399.3j27.30.0....0...1c.1.64.psy-ab..0.9.1124...0j0i67k1j0i10i19k1j0i19k1j0i30i19k1j0i13i30i19k1j0i13k1j0i13i30k1j0i8i13i30i19k1.0.kwnN-b-s9cw#imgrc=UG-1shEh098mIM
:
https://www.google.ba/search?biw=1229&bih=607&tbm=isch&sa=1&ei=EZCVWp_IOMLQkwWOqoZg&q=cofirm+study+falodex+breast&oq=cofirm+study+falodex+breast&gs_l=psy-ab.3...5750.15813.0.16060.33.30.3.0.0.0.160.3399.3j27.30.0....0...1c.1.64.psy-ab..0.9.1124...0j0i67k1j0i10i19k1j0i19k1j0i30i19k1j0i13i30i19k1j0i13k1j0i13i30k1j0i8i13i30i19k1.0.kwnN-b-s9cw#imgrc=u1eemeiqEaTdwM
:
SOFEA
ana+ful, PFS jednak
https://www.youtube.com/watch?v=4p6AnkK01ic
https://www.ncbi.nlm.nih.gov/pubmed/23902874
1L
FALCON
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(16)32389-3/abstract?code=lancet-site
Tamoxifen +/- LHRH agonist (buserelin)
SS OS 3.7 vs 2 y za LHRL
mTOR
BOLERO 2
2L, eve+ful, 7 vs 3 mj, HR 0.43
https://www.nejm.org/doi/full/10.1056/NEJMoa1109653
TAMRAD
https://www.ncbi.nlm.nih.gov/pubmed/22565002
BALLET
https://clinicaltrials.gov/ct2/show/NCT02028507
studije
BOLERO 6
PD na Letr ili Ana, Eve+Exxevs Evevs kape, PFS 8vs8vs7 mj, OS=
epigenetika
ENCORE 301
https://www.nejm.org/doi/full/10.1056/NEJMoa1109653
PIK
studije
FERGIE
https://www.ncbi.nlm.nih.gov/pubmed/27155741
BELLE
https://www.ncbi.nlm.nih.gov/pubmed/28576675
SANDPAPER
dizajn, Tase+Ful vs FUL u 2L, NAKON pd na AI ili 1L kt
+, rez 7.5 vs 5.5 PFS, GR 0.66
Kemoterapija
Taxol
BR07
CG
kontrola bolesti
nastaviti vs prekinut
nastavaiti
PFS 7.5vs4 mj, OS 33vs23 mj
Bisfosfonati
Zometa
CALGB-70604
https://www.google.ba/search?q=CALGB-70604&tbm=isch&source=lnms&sa=X&ved=0ahUKEwi9jMLc18TZAhXLKewKHfN0CSkQ_AUICigB&biw=1229&bih=607&dpr=1.56#imgrc=O801uaMkCoam1M
:
Denosumab
http://www.xgeva.com/hcp/overview/
PARP inhibitori
svi
https://www.google.ba/search?q=parp+inhibitor+breast+cancer+study&source=lnms&tbm=isch&sa=X&ved=0ahUKEwiTv9TXv-naAhUHQJoKHbQcCvoQ_AUICigB&biw=1229&bih=587#imgrc=NSd6sZ7zLF_8OM
:
tiimline
https://www.google.ba/search?q=parp+inhibitor+breast+cancer+study&source=lnms&tbm=isch&sa=X&ved=0ahUKEwiTv9TXv-naAhUHQJoKHbQcCvoQ_AUICigB&biw=1229&bih=587#imgrc=fvp1zR_e8hvn8M
:
dizajn studija
https://www.google.ba/search?q=parp+inhibitor+breast+cancer+study&source=lnms&tbm=isch&sa=X&ved=0ahUKEwiTv9TXv-naAhUHQJoKHbQcCvoQ_AUICigB&biw=1229&bih=587#imgrc=tdNiwkrApxA7wM
:
olaparib
talazoparib
dizajn
https://www.google.ba/search?q=talazoparib+breast+cancer&source=lnms&tbm=isch&sa=X&ved=0ahUKEwj9g5OQwunaAhVhQJoKHTYCDUoQ_AUICigB&biw=1229&bih=548#imgrc=cbsGb0ssCEo1sM
:
rezultati
https://www.onclive.com/conference-coverage/sabcs-2017/talazoparib-improves-pfs-in-brcapositive-breast-cancer
EMBRACE
OLYMPIAD
https://www.nejm.org/doi/full/10.1056/NEJMoa1706450
CDK 4/6
LIJEKOVI
Palbo
PALOMA1, 2, 3
https://www.youtube.com/watch?v=ZLyP_SeQ9p8
studije
PALOMA 1
https://www.thelancet.com/journals/lanonc/article/PIIS1470-2045(14)71159-3/abstract?code=lancet-site
PALOMA 2
https://www.nejm.org/doi/full/10.1056/NEJMoa1607303
PALOMA 3
https://www.thelancet.com/journals/lanonc/article/PIIS1470-2045(15)00613-0/abstract?code=lancet-site
PEARL
https://www.youtube.com/watch?v=3e99lfmmDN0
https://clinicaltrials.gov/ct2/show/NCT02028507
Ribociklib
studije
MONALEESA-2
https://www.youtube.com/watch?v=3kQ_p2EZX4Q
https://www.nejm.org/doi/full/10.1056/NEJMoa1609709
MONALISA 7
preme, post
tamo, Letrozol
PFS 23 vs 13 mj
https://coggle.it/diagram/WobQ-SGMFQABCvYk/t/metastatic%2C-lad
MONALISA 3, + U 1 ili 2l, PFS 20VS12 MJ; orr30VD20%, ae: HEMATOLOŠKI, OPČI
Abema
MONARCH 2
sa nas, letrozolom
PFS 50% bolji
https://www.ncbi.nlm.nih.gov/pubmed/28580882
A+Ful+LHRH, nrvs10 mj, 60 vs30% ORR, CRR3%
studije
moduli
CDK/mTOR
studije
PASTOR
TRINITI-1
CDK+IT
PACE
CDK+anti HER u Luminalaca
PATINA
MONARCHer
adjuvatno
PALLAS
MonarchE
AE
najčešće
granulocitopenija
zbog zaustavljanja staničnosg ciklusa
vs
kemo
1 more item...
% prva 2 ciklusa, 14 dan
nema
povećanja apoptoze
utjecaja na dstupnost
nema < totalne celularnosti KM
smanjena proliferacija
za pauza, redukcija
rijeđer
GI
mučnina
proljev-češće kod ameba G3
PE
2%
QTC >480 ms-3%, asimptomatski
porasst jetrenih enzima
CML, 15 slučajeva
studije u tijeku
PENELOPE
nakon neoadj rezdidualne, 1y
PALLAS
adjuvantno+enokrina th
MOA
https://www.google.ba/search?q=cdk+4/6+breast+cancer&source=lnms&tbm=isch&sa=X&ved=0ahUKEwidz4zbw-naAhWFJJoKHZIBDSYQ_AUICigB&biw=1229&bih=548#imgrc=ivVWmXbWtbYeDM
:
https://www.google.ba/search?q=cdk+4/6+breast+cancer&source=lnms&tbm=isch&sa=X&ved=0ahUKEwidz4zbw-naAhWFJJoKHZIBDSYQ_AUICigB&biw=1229&bih=548#imgrc=h8FqOnvhT-rY8M
:
razlike
https://www.google.ba/search?q=abemaciclib+and+palbociclib+difference&source=lnms&tbm=isch&sa=X&ved=0ahUKEwjUgMfCx-naAhUGEJoKHViFA1UQ_AUICigB&biw=1229&bih=548#imgrc=_9-wXOglglck8M
:
algoritmi
HER
timeline
https://www.google.ba/search?q=metastatic+breast+cancer+therapy&source=lnms&tbm=isch&sa=X&ved=0ahUKEwjThu_LrunaAhWkE5oKHcXuCtgQ_AUICigB&biw=1229&bih=587#imgrc=-zUXBZVqYFAYCM
:
studije
pivotalne
https://www.google.ba/search?q=HER2-Directed+Therapy+for+Metastatic+breast&source=lnms&tbm=isch&sa=X&ved=0ahUKEwj20JvdsOnaAhXLbZoKHWjMCgQQ_AUICigB&biw=1229&bih=587#imgrc=p3GW72gpRh4eqM
:
HR+, HER 1L
https://www.google.ba/search?q=metastatic+breast+cancer+her+therapy&source=lnms&tbm=isch&sa=X&ved=0ahUKEwjjh5aksOnaAhXjFZoKHbJMAhAQ_AUICygC&biw=1229&bih=587#imgrc=MX5dFzYVA59Y4M
:
1, 2, 3L
https://www.google.ba/search?q=HER2-Directed+Therapy+for+Metastatic+breast&source=lnms&tbm=isch&sa=X&ved=0ahUKEwj20JvdsOnaAhXLbZoKHWjMCgQQ_AUICigB&biw=1229&bih=587#imgrc=C6VC6ir_A8lheM
:
shema MOA
https://www.google.ba/search?q=HER2-Directed+Therapy+for+Metastatic+breast&source=lnms&tbm=isch&sa=X&ved=0ahUKEwj20JvdsOnaAhXLbZoKHWjMCgQQ_AUICigB&biw=1229&bih=587#imgrc=aPOpfp6y2u6E0M
:
https://www.google.ba/search?q=HER2-Directed+Therapy+for+Metastatic+breast&source=lnms&tbm=isch&sa=X&ved=0ahUKEwj20JvdsOnaAhXLbZoKHWjMCgQQ_AUICigB&biw=1229&bih=587#imgrc=4u-mPCk8rgTC6M
:
https://www.google.ba/search?q=HER2-Directed+Therapy+for+Metastatic+breast&source=lnms&tbm=isch&sa=X&ved=0ahUKEwj20JvdsOnaAhXLbZoKHWjMCgQQ_AUICigB&biw=1229&bih=587#imgrc=CzZJ7RhK68uwWM
:
MOA
https://www.google.ba/search?q=immunotherapy+activation+and+inhibition&source=lnms&tbm=isch&sa=X&ved=0ahUKEwiZvpKH1OnaAhXrF5oKHTUiC8EQ_AUICigB&biw=1229&bih=548#imgrc=wae8Y90O9FBVmM
:
rezistencija
https://www.google.ba/search?q=her+breast+cancer+resistance&source=lnms&tbm=isch&sa=X&ved=0ahUKEwjM3Oz3zunaAhUoyqYKHXFfD9sQ_AUICigB&biw=1229&bih=548#imgrc=RFjbREq6AHXU0M
:
NCCN
https://www.nccn.org/professionals/physician_gls/pdf/breast.pdf
2L, HER 59str
ER +
https://www.google.ba/search?q=cdk+4/6+breast+cancer&source=lnms&tbm=isch&sa=X&ved=0ahUKEwidz4zbw-naAhWFJJoKHZIBDSYQ_AUICigB&biw=1229&bih=548#imgrc=weTzlcc9QXS1OM
:
rezistencija
https://www.google.ba/search?q=metastatic+breast+cancer+resistance+to+therapy&source=lnms&tbm=isch&sa=X&ved=0ahUKEwiAtMbTzunaAhXLxaYKHfvUAO8Q_AUICigB&biw=1229&bih=548#imgrc=qPFJ57VTBWZQIM
:
imunoterapija
studije
studije zbirno
https://www.google.ba/search?q=keynote+086&source=lnms&tbm=isch&sa=X&ved=0ahUKEwie3vWJ0unaAhWiF5oKHS7RA_YQ_AUICigB&biw=1229&bih=548#imgrc=Bh9GcXgH1ijvQM
:
ishodi generalno
https://www.google.ba/search?q=immunotherapy+breast+cancer+study&source=lnms&tbm=isch&sa=X&ved=0ahUKEwi366H-z-naAhVIApoKHYSPAzIQ_AUICigB&biw=1229&bih=548#imgrc=ZNWAI6j0SSkEKM
:
na Harvardu studije
https://www.google.ba/search?q=immunotherapy+breast+cancer+study&source=lnms&tbm=isch&sa=X&ved=0ahUKEwi366H-z-naAhVIApoKHYSPAzIQ_AUICigB&biw=1229&bih=548#imgrc=09VjqjeHppMgaM
:
atezo u TN pretretitani
http://www.ascopost.com/issues/may-25-2017/atezolizumab-improves-overall-survival-in-small-subset-of-patients-with-triple-negative-breast-cancer/
IMPasion, f3
pembro
pretretirani, KN 086
http://ascopubs.org/doi/abs/10.1200/JCO.2017.35.15_suppl.1008
RR 23% PD L +
KN 012
TN, RR18%, OS>11 mj
mutacijski load
https://www.google.ba/search?q=immunotherapy+breast+cancer+study&source=lnms&tbm=isch&sa=X&ved=0ahUKEwi366H-z-naAhVIApoKHYSPAzIQ_AUICigB&biw=1229&bih=548#imgrc=7-l9Ncu3jZvV8M
:
KONGRESI
asco
horm poz
https://www.primeoncology.org/online-education/oncology/hr-positive-breast-cancer-updates-chicago-2018/clinical-spotlight/