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Pierce's Disease Solutions - Coggle Diagram

- - - - Phage engineering
        
        Modify phage to better attack Xf
        
        Perpetually evolving phages
        
        Evo 2 generative phage design
      - Delivery routes
        
        Spray on vines (vs. injection)
        
        Add to irrigation water
        
        Inoculate soil before planting
        
        Arrows laced with phage
        
        Birds / pollinators carry it
        
        Deliver via the GWSS themselves
    - - Phage injects resistance into GWSS
      - Contagious resistance phage
      - Infect GWSS so they become resistant
  - - - T-cell-like adaptive immunity
      - CRISPR-like immune system
      - Plant vaccine
      - Virus that confers resistance
      - Gene therapy for grapes
      - Stack many resistance genes
    - - Vine makes anti-Xf phage proteins
      - More tyloses + phage protein
      - Explodes when infected (kills Xf)
    - - Leaf-specific deterrent compound
      - Vine makes anti-GWSS phage proteins
    - - Upregulate tyloses
      - Less reliant on water
      - Desiccation-resistance genes
    - - Communicate with helpful plants
      - Plant extracellular vesicles
  - - - Gene drive to kill GWSS
      - Flyttr-like drive to reduce GWSS
      - Dominant sterile males
    - - Gene drive for Xf-resistant GWSS
      - Release resistant bugs to outcompete
      - Anti-malarial-style vector control
  - - - Silence Xylella genes
      - Silence GWSS genes
  - - - Benevolent Xf strain
      - Commensal bacteria w/ protective genes
    - - Predators that eat GWSS
      - Import predators from SE USA
- - - - Drug the plants
      - Antibacterial treatment
      - Destroy bacterial cells
    - - Break biofilm strands
      - Remove biofilm from xylem
      - Flush Xf out with fluids
  - - - Repellent aerosol
    - - Ant-bait-style poison