Please enable JavaScript.

Coggle requires JavaScript to display documents.

Liver fluke disease, Learning Objectives, 44 - 26 - 23 - 17 - Coggle…

- - - - Screening - Searching for eggs in stool
      - Treatment - Praziquantel
- - - - SE Asia
    - - Highest prevalence of infection
  - - - Cholangiocarcinoma
- - - - Damage causes regeneration / reformation of cells
        
        Overflow of cells causes cancer
        
        Hyperplasia (Uncontrolled cell division / Cancer)
  - - - Pro-inflammatory theory
        
        "Magnitude of inflammatory response determines infection outcome"
- - - - Worsening APF
      - No Opisthorchis viverrini
    - - Decreasing Opisthorchis viverrini
    - - Found in the gut of O. viverrini
        
        Co-infection
      - Praziquantel is the reason
        
        Kills O. viverrini
        
        Releases H. pylori
        
        Releases neutrophil chemoattractants & activators
      - Symptoms
        
        Gastric
        
        Inflammation
        
        Cancers
        
        CagA
        
        Major pathogenicity protein
        
        Found in O. viverrini infected cases
        
        Induces TLR2 / NLRP3 inflammasome