Please enable JavaScript.

Coggle requires JavaScript to display documents.

Mycobacterium Bovis, Learning objective - Coggle Diagram

- - - - Alveolar macrophages are the first line of defence, but the first infected
  - - - Phosphatases
      - Effectors
      - Prevents recruitment of V-ATPase proton pumps
        
        No acidification in the phagosome
        
        No activation of hydrolytic enzymes
  - - - Recruits immune systems
      - Cytokines
      - Chemokines
    - - Planned cell death
      - Releases living M. bovis
      - Taken up by other immune cells
    - - Travels to the lymphnodes to Prime CD4+ T-cells
        
        Adaptive immunity
  - - - Cluster of immune cells, walling off any organism that isn't able to be eliminated
      - Central
        
        Caseous necrosis
        
        Cell death
        
        White, soft & crumbly
        
        Bacilli
      - Surrounding cuff
        
        Epithelioid cells
        
        Giant cells
        
        Foamy macrophages
      - Outer layer
        
        T cells
        
        B cells
        
        Fibroblasts
      - Contains the infection, but a reservoir for persistence
- - - - Promotes necrosis in macrophages
  - - - Airways
      - Blood
      - Lymphatics
  - - - Macrophages >> Foamy macrophages
        
        Lipid rich
      - Lipid accumulation
        
        Central caseous necrosis
        
        Collapses the core granuloma
- - - - Badger
    - - Brushtail Possum
    - - Kudu
      - Buffalo
      - Warthog
    - - White-tailed deer
- - - - Cattle >> Wildlife
      - Wildlife >> Cattle
  - - - Complex
      - Expensive
- - - - M. bovis PPD
        
        Purified protein derivative
      - M. avium PPD
      - Small concentration
  - - - M. bovis > M. avium
        
        Positive
        
        Swelling
        
        Culling
      - M. bovis = M. avium
        
        Inconclusive
        
        Tested 60 days later