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DISEASES OF MOVEMENT, HYPOKINETIC DISORDERS - Coggle Diagram

- - - - Clinical: Involuntary, Repetitive Movements (e.g., Facial)
      - NEUROTRANSMITTER INCREASED: Dopamine (DA) activity
      - STRUCTURE INJURED: Striatal DA Receptors
      - Neural Change: Dopamine Receptor Supersensitivity
      - Mechanism: Chronic Antipsychotic Exposure
    - - Clinical: Chorea, Dementia, Psychiatric
      - NEUROTRANSMITTER INCREASED/ALTERED: Dopamine (DA)
      - NEUROTRANSMITTER DECREASED: GABA & ACh
      - STRUCTURE INJURED: Caudate Nucleus (Severe atrophy) & Putamen
      - Mechanism: CAG trinucleotide repeat expansion