Please enable JavaScript.

Coggle requires JavaScript to display documents.

(Haemoglobin) - Coggle Diagram

- - - - Oxyhemoglobin state
        where O2 binding moves the iron atom into the porphyrin plane, rupturing salt bridges between dimers
        produce a high O2 affinity conformation
    - - Deoxyhemoglobin state
        strong ionic salt bridges and hydrogen bonds between alpha-beta dimers (stronger interaction)
        resulting in low O2 affinity
  - - - distal histidine (E7)
        
        stabilize oxygen (O2) when it binds
      - hydrophobic pocket
        
        Shields the iron (Fe2+) from water to prevent it from oxidizing into non-functional ferric iron (Fe3+)
      - proximal histidine (F8)
        
        binds the ferrous iron of the heme group directly to the globin chain.
    - - Hbf
        
        2 Alpha 2 Gamma
      - HbA
        
        2 Alpha 2 Beta
      - Hbs
      - HbA2
        
        2 Alpha 2 Delta