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Jaundice - Coggle Diagram

- - - - mechanical
        
        Microangiopathic haemolytic anaemia
        DIC - has precipitating event
        
        significant activation of clotting factors
        
        clots break down
        STOPMT: snake bites, sepsis, trauma, obstetric, pancreatitis, malignancy (APML), transfusion
        
        TTP
        
        autoimmune or congenital
        
        HUS
        
        post e.coli 157 infection
        
        HELLP
        
        pregnancy: Haemolysis, elevated liver enzymes, low platelets
        
        Hypertensive emergency
        
        Macroangiopathic Haemolytic anaemia
        
        metallic heart valve
      - Immune mediated
        
        Autoimmune
        
        Warm - IgG
        
        SLE
        
        Drug allergies, methylpenicillin, methyldopa
        
        Cold
        
        Mycoplasma infection
        EBV
        
        Alloimmune
        
        Transfusion reaction
        
        Haemolytic disease of the newborn and fetus
    - - Haemoglobinopathy
        
        Thalassemia B
        chipmunk face
        bow legs
        basically extramedullary haematopoiesis
        
        Sickle Cell Anaemia
        RF: Afro-carribean
        Presentation: sharp pain across the whole body, ischaemia and infarction through blockage of small capillaries
        Cx:
      - Enzyme deficiency
        
        G6PD:
        Precpitated by fava beans and anti-malarias (primaquine) and ciprofloxacin, maybe bactrim
        RFs: X linked inheritance
        
        Pyruvate kinase deficiency
      - hereditary micropherocytosis
- - - - haemachromatosis
        
        bronze pigmentation
      - Wilson's
        
        secondary parkinsonian symptoms
        
        kayser fleish rings
      - A1AT deficiency
  - - - Hep A, B, E
        Always ask the RFs for A like shellfish, B for sexual activity and IVDU, and E for interaction with swine