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Sepsis - Coggle Diagram

- - - - 4.5 g IV TDS–QDS
    - - 1 g IV TDS
    - - 1.2 g IV TDS
  - - - 15–20 mg/kg IV loading → maintenance per levels
    - - 600 mg IV/PO BD
  - - - 2 g IV TDS
    - - 2 g IV BD–TDS
  - - - 30 mL/kg within first 3 hours
    - - Dynamic measures
      - Avoid overload
  - - - 0.01–0.5 mcg/kg/min IV infusion
      - Titrate to MAP ≥65
  - - - Fixed 0.03 units/min
      - Added when NE ≥0.25 mcg/kg/min
  - - - 0.01–0.3 mcg/kg/min
  - - - 200 mg/day IV (e.g., 50 mg QDS)
      - For pressor‑dependent shock
  - - - Paracetamol 1 g QDS
- - - - Bacterial toxins
      - Cell injury signals
  - - - IL‑6
      - TNF‑α
    - - Capillary leak
      - Hypotension
- - - - Steroids
      - Chemotherapy
- - - - Staphylococcus aureus
      - Streptococcus pneumoniae
    - - E. coli
      - Klebsiella
      - Pseudomonas
  - - - Influenza
      - COVID‑19
    - - Candida
    - - Malaria
- - - - Excessive inflammation
      - Immune suppression
    - - Cardiovascular
      - Respiratory
      - Renal
      - Neurological