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Innate lymphoid cells - Coggle Diagram
Innate lymphoid cells
ILC2
Key membrane markers: CRTH2, ST2, CD127, CD161
Key TFs: GATA3, RORα, GFI
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Key effector molecules: IL-4, IL-5, IL13
activated by: IL-25, IL-33, TSLP
plasticity: ILC2 to ILC1
Promoted by: IL-12, IL-1β
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Plasticity ILC2 to ILC3
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Functional change: ↑ IL-17, IL-22
ILC3
Key membrane markers: CD117, CD127, CD161
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key effector molecules: IL-17, IL-22, GM-CSF, lymphotoxin
activated by: IL-23, IL-6, IL-1, TLR 2/4, AHR ligands
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ILC1
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Key effector molecules: IFNγ, TNFα
Key TFs: Tbet, RUNX3, TCF-1
activated by: IL-12, IL-15, IL-18
Key membrane markers: CD49a. CD127, CD161
NK cells
Key membrane markers: CD49b, CD56
Key TFs: Tbet, EOMES, Hobit
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Key effector molecules: Granzyme B, perforin, IFNγ, TNFα
activated by: balance of activatory and inhibitory receptors (KIRs, NCRs vs NKG2a, Siglec 7