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Tumor lysis syndrome Acute metabolic Emergency, leads to - Coggle Diagram
Tumor lysis syndrome
Acute metabolic Emergency
Identification of Deterioration
Pathophysiology
Risk factors:
High tumor burden: ALL, AML, Burkit lymphoma
Spontaneous TLS¹ or chemotherapy initiated
Rapid cell turnover - elevated LDH
Rapid tumor lysis
Intracellular contents into bloodstream
↑ pottasium → Hyperkalaemia →arrythmias
↑ phosphate → hyperphosphataemia →binds with calcium
nucleic acid breakdown → uric acid ↑ →tubular crystal deposition → AKI
Renal consequences
urate + calcium-phosphate crystal nephropathy
Aki → oliguria
Secondary Hypocalcemia
Tetany, seizures, prolonged QT
Calcium binds with excess phosphate
Life threatening deterioration
Cardiac arrest, seizures, renal failure
Diagnosis and monitoring
Cairo-Bishop criteria 1 Laboratory TLS and Clinical TLS
Link Title
leads to