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ANEMIA APLASICA, BIBILIOGRAFIA, FIGUEROA COVARRUBIAS PEDRO JOSE - Coggle…
ANEMIA APLASICA
ETIOLOGIA
Adquirida
Idiopática → la más frecuente
Inmunomediada
Fármacos
Tóxicos → benceno
Infecciones
Hepatitis asociada a AA
Enfermedades autoinmunes
Hereditaria
Anemia de Fanconi
Telomeropatías / disqueratosis congénita
Shwachman-Diamond
Diamond-Blackfan
GATA2
SAMD9/SAMD9L
Trombocitopenia amegacariocítica congénita
CLINICA
Anemia de Fanconi
ANEMIA
Palidez
Fatiga
Astenia
Taquicardia
Disnea
Cefalea
Irritabilidad
Intolerancia al ejercicio
↓ rendimiento escolar
⚪ NEUTROPENIA
Fiebre
Infecciones recurrentes
Mucositis
Gingivitis
Neumonía
Bacteriemia
Sepsis
Infecciones fúngicas
TROMBOCITOPENIA
Petequias
Equimosis
Epistaxis
Gingivorragia
Hematuria
Sangrado GI
Menorragia en adolescentes
Hemorragia intracranea
DIAGNOSTICO
Biometría hemática
Pancitopenia
Reticulocitopenia
Neutropenia
Trombocitopenia
Anemia
iopsia:
Hipocelularidad marcada
Sustitución grasa
↓ eritropoyesis
↓ granulopoyesis
↓ megacariocitos
FISIOPATOLOGIA
TRATAMIENTO
DEFINCION
síndrome de insuficiencia medular caracterizado por pancitopenia periférica asociada con hipocelularidad marcada de la médula ósea y ausencia de infiltración neoplásica, fibrosis significativa o reemplazo medular que explique las citopenias.
GRAVEDAD
BIBILIOGRAFIA
cheinberg, P., O’Neal, D. A., Basquiera, A. L., Byrne, M. T., Calado, R. T., Desai, R., DeZern, A. E., Dufour, C., Groarke, E. M., Han, H., Hosokawa, K., Kansal, R., Kulasekararaj, A. G., Mossad, S. B., Muus, P., Patel, B. J., Risitano, A. M., Schrezenmeier, H., Sharma, A., ... Neumann, I. (2026). American Society of Hematology 2026 guidelines for the diagnosis and management of severe acquired aplastic anemia. Blood Advances.
https://doi.org/10.1182/bloodadvances.2025019051
Babushok, D. V., DeZern, A. E., de Castro, C. M., Rogers, Z. R., Beenhouwer, D., Broder, M. S., ... et al. (2024). Modified Delphi panel consensus recommendations for management of severe aplastic anemia. Blood Advances, 8(15), 3946–3960.
https://doi.org/10.1182/bloodadvances.2023011642
Kulasekararaj, A., Cavenagh, J., Dokal, I., Foukaneli, T., Gandhi, S., Garg, M., Griffin, M., Hillmen, P., Ireland, R., Killick, S., Mansour, S., Mufti, G., Potter, V., Snowden, J., Stanworth, S., Zuha, R., & Marsh, J. (2024). Guidelines for the diagnosis and management of adult aplastic anaemia: A British Society for Haematology guideline. British Journal of Haematology, 204(3), 784–804.
https://doi.org/10.1111/bjh.19236
Pacheco-Orozco, R. A., Devia, A., Manzi, E., Franco, A. A., Pachajoa, H., & Medina Valencia, D. (2024). Next generation sequencing in pediatric bone marrow failure: A valuable tool for accurate diagnosis. Andes Pediatrica, 95(5), 525–532.
https://doi.org/10.32641/andespediatr.v95i5.5066
Guo, H., Liu, C., Kang, L., Liu, C., & Liu, Y. (2024). Safety and efficacy of eltrombopag in patients with aplastic anemia: A systematic review and meta-analysis of randomized controlled trials. Hematology, 29(1), 2335419.
https://doi.org/10.1080/16078454.2024.2335419
Zhang, Y., Li, J., Li, X., Geng, Q., Xie, Y., Zhang, G., Wei, M., & Ma, Y. (2024). Efficacy and safety of immunosuppressive therapy combined with eltrombopag for severe aplastic anemia: A systematic review and meta-analysis. Systematic Reviews, 13, 101.
https://doi.org/10.1186/s13643-024-02515-2
Iftikhar, R., DeFilipp, Z., DeZern, A. E., Pulsipher, M. A., Bejanyan, N., Burroughs, L. M., ... et al. (2024). Allogeneic hematopoietic cell transplantation for the treatment of severe aplastic anemia: Evidence-based guidelines from the American Society for Transplantation and Cellular Therapy. Transplantation and Cellular Therapy, 30(12), 1155–1170.
https://doi.org/10.1016/j.jtct.2024.09.017
Piekarska, A., Pawelec, K., Szmigielska-Kapłon, A., & Ussowicz, M. (2024). The state of the art in the treatment of severe aplastic anemia: Immunotherapy and hematopoietic cell transplantation in children and adults. Frontiers in Pediatrics.
DeZern, A. E., & Churpek, J. E. (2021). Approach to the diagnosis of aplastic anemia. Blood Advances, 5(12), 2660–2671.
https://doi.org/10.1182/bloodadvances.2021004345
[Estudio pediátrico sobre falla medular] (2021). Pediatric bone marrow failure: Clinical, hematological and targeted next generation sequencing data. Blood Cells, Molecules, and Diseases, 89, 102510.
https://doi.org/10.1016/j.bcmd.2020.10251
FIGUEROA COVARRUBIAS PEDRO JOSE
