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Urea Protein breakdown Uric acid Purines (red meat, alcohol, high fructose) Creatinine Muscular creatine phosphate
Protein breakdown
Purines (red meat, alcohol, high fructose)
Muscular creatine phosphate
Behind peritoneum
Where vessels, ureters & nerves enter & exit
Cone-shaped renal pyramids Pyramid separated by renal columns Inward extensions of cortical tissue
Inward extensions of cortical tissue
Segmental arteries branch into interlobar arteries Arcuate arteries branch from interlobar arteries
More than 1 million nephrons in each kidney
Posterior pituitary secretes antidiuretic hormone (ADH)
99% of filtrate is resorbed bye tubules
Hold back all but the smallest proteins Allows passage of water, ions, glucose, amino acids, urea
The descending side is freely permeable to water Ascending side pumps salt out into medulla This pulls water out of descending limb & concentrates the urine
This pulls water out of descending limb & concentrates the urine
Glomerulus Peritubular capillaries in cortical nephrons or vasa recta in juxtamedullary nephrons
Low-pressure, porous capillaries All molecules secreted by nephrons into urine are from peritubular capillaries
Descend into the medulla
Renin is secreted in response to failing/low blood pressure in afferent arteriole Causes kidney to retain more salt, to attract more water, to increase blood volume
Initiates renin-angiotensin mechanism
Inner longitudinal layer Outer circular layer
Full bladder is spherical Expands into the abdominal cavity Empty bladder Lies entirely within pelvis
Expands into the abdominal cavity
Lies entirely within pelvis
The prostate lies directly inferior to bladder Surrounds the urethra
3-4cm
20cm 3 named regions
Filtrate of blood leaves kidney capillaries
Most nutrients, water & essential ions reclaimed
Active process of removing undesirable molecules
Nephrons decrease in size & number Tubules are less efficient at secretion & resorption Secretion: taking what's in the capillaries & moving it into the tubules to be removed Resorption: nutrients in the tubules that need to be kept go into the surrounding capillaries Filtration declines Recognition of desire to urinate is delayed Loss of muscle tone in the bladder
Secretion: taking what's in the capillaries & moving it into the tubules to be removed Resorption: nutrients in the tubules that need to be kept go into the surrounding capillaries