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Cystic Fibrosis: How a Defective CFTR Transporter Causes Disease - Coggle…
Cystic Fibrosis: How a Defective CFTR Transporter Causes Disease
Cause: CFTR Gene Mutation
Mutation changes the CFTR protein
Defective CFTR chloride transporter
Normal Cell (Healthy)
CFTR channel works properly
Chloride (Cl⁻) moves out of the cell
Water follows chloride movement
Mucus stays thin and watery
Airways remain clear
Normal breathing
Cystic Fibrosis Cell (Defective)
CFTR channel does not work correctly
Chloride (Cl⁻) cannot leave the cell
Less water moves into mucus
Mucus becomes thick and sticky
Mucus builds up in airways
Blocked airways
Difficulty breathing
Frequent lung infections
Persistent coughing
Overall Effect
Faulty membrane transport
Problems maintaining water balance
Cystic Fibrosis Symptoms