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Systemic Lupus Erythematosus - Coggle Diagram
Systemic Lupus Erythematosus
Altered Physiology
Genetic Predisposition + Environmental Triggers
Loss of self-tolerance
Autoantibody production (ANA, anti-dsDNA)
Immune complex formation
Immune complex deposition
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Complement activation
Inflammation
Multi-system tissue damage
Skin
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Immune complex deposition in skin
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Complement activation
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Inflammation
Tissue injury
Malar rash
Photosensitivity
UV-induced cell damage
Immune activation
Disease flare
Musculoskeletal
Immune complex deposition
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Synovial inflammation
Cytokine release
Joint swelling
Pain
Arthralgia
Chronic inflammation
Joint stiffness
Renal
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Immune complex deposition in glomeruli
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Complement activation
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Glomerular inflammation
Lupus nephritis
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Increased glomerular permeability
Proteinuria
Glomerular damage
Decreased filtration efficiency
Hematuria
Renal dysfunction
RAAS activation
Hypertension
Cardiovascular
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Immune complex deposition
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Inflammation of pericardium
Pericarditis
Chest pain
Chronic systemic inflammation
Endothelial injury
Accelerated atherosclerosis
Plaque formation
Increased risk of MI and stroke
Pulmonary
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Inflammation
Pleural effusion
Reduced lung expansion
Shortness of breath
Immune complex deposition
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Pleural inflammation
Pleuritis
Chest pain with respiration
Hematologic
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Autoantibody production
Autoimmune destruction of blood cells
Decreased RBC count
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Anemia
Fatigue
Decreased WBC count
Leukopenia
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Increased infection risk
Decreased platelet count
Thrombocytopenia
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Increased bleeding risk
Neurologic
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Inflammation + vascular injury
Reduced cerebral perfusion
Neurologic dysfunction
Headaches
Neuronal injury
Cognitive dysfunction
Severe CNS involvement
Seizures
Treatments
Hydroxychloroquine
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Modulates immune response
Reduces disease flares
Corticosteroids
Decrease inflammation
Immunosuppressants
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Reduce autoantibody production
Reduce tissue damage
Sun protection
Reduces UV-triggered flares
Systemic Manifestations
Systemic Inflammation
Fatigue
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Fever
Malaise
Weight loss
Diagnostics
ANA positive
Non-specific evidence of autoimmune activity
Indicates loss of self-tolerance
CBC
Anemia
Leukopenia
Thrombocytopenia
Anti-dsDNA positive
Strongly supports SLE dx
Associated with lupus nephritis
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Low complement levels (C3/C4)
Evidence of complement consumption
Suggests active disease
UA
Proteinuria/hematuria
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Evidence of renal involvement