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RTK, APC mutation means truncated central scaffold, :forbidden:, RTK…
RTK
Constitutively activated KRAS protein
Activates MEK
LRP6
MEK-induced p-LRP6
FZD
Wnt pathway becomes ligand-independent
Destruction complex (DC) without its central scaffold is broken
Beta-catenin builds up greatly in the cytoplasm
Beta-catenin moves to the nucleus to bind with TCF/LEF transcription factors
Wnt target genes are turned on
3 more items...
Displaces inhibitory Groucho on the DNA
Recruits adaptors like PYGO and BCL9
Axin, GSK3 and CK1 are no longer held together
Activates ERK
APC mutation means truncated central scaffold
:forbidden:
RTK stimulation is not needed for mutated KRAS
Receptor Priming