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Systemic Lupus Erythematosus, Musculoskeletal System - Coggle Diagram
Systemic Lupus Erythematosus
Integumentary/Immune System
Causes
sunlight triggers immune overreaction
inflammation develops in skin layers
immune system attacks skin cells
Affects
increased reaction to sunlight
skin barrier irritated
skin becomes inflamed and sensitive
Manifestations
sun sensitivity
rashes (sun-exposed areas)
hair loss
Treatment
anti-inflammatory medication
corticosteroids
NSAIDs
suppress immune system
methotrexate
mycophenolate mofetil
azathioprine
target immune system (long-term)
biologic drugs (belimumab)
symptom and lifestyle management
rest (during flare ups)
stress management
sun protection
healthy diet/exercise
Cardiovascular/Respiratory System
Affects
irritated lung and heart linings
breathing
blood vessels
Manifestations
shortness of breath, pain with deep breathing
pericarditis (inflammation around heart)
chest pain
Causes
inflammation of lung lining
inflamed BV
inflamed heart lining
Nervous System
Manifestations
memory problems
mood changes
headaches
seizures
Affects
brain function
nerve communication
cognitive function
Causes
altered nerve signaling
blood flow to brain
immune system triggers brain tissue damage
Diagnostics
CBC (complete blood count)
low WBC
low platelets
low RBC
ANA test (antinuclear antibody)
positive (immune system is attacking body)
urinanalysis
blood
protein
kidney biopsy
anti-ds DNA or anti-smith antibodies
symptoms/signs
joint pain
fatigue
rash
chest pain/breathing
neurologic function
Renal System
Affects
protein + waste leak into urine
fluid balance is disrupted
cannot filter blood
Manifestations
edema
fatigue
proteinuria
high BP
Causes
inflammation damages tissue
filtration system irritated
immune complexes deposit in glomeruli
Musculoskeletal System
Affects
Movements feel weak
Immune proteins build up in joint tissue
Joints become swollen and irritated
Causes
immune complexes build up in joint tissue
causes joint inflammation
immune system attacks joints
Manifestations
joint pain, swelling, stiffness, aches, and fatigue