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Vasculitis, Immune system - Coggle Diagram
Vasculitis
alterations in physiology leading to disease state
microvascular wall damage
Increased small vessel permeability
Fibrinoid necrosis of vessel wall
Repeated injury
Structural remodeling of vessel
Chronic inflammation
macrovascular wall damage
aneurysm formation
Stenosis
Cumulative vascular alterations
hemodynamic disruption
reduced tissue perfusion
Ischemia
organ damage
Endothelium dysfunction
Pro-inflammatory
Pro-thombotic
clot formation
occlusions
Clinical manifestations
Fever/fatigue
Multi-system alterations in function
Treatment modalities
Immune system
Environmental exposure
Infection
Medication
Activated T lymphocyte infiltration of vessel wall
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Cytokine release--> activation of macrophages
Granuloma formation
Macrophage enzymes degrade elastic lamina and smooth muscle layers
vessel wall thickening, fibrosis, lumen narrows
Cytokines recruit additional immune cells
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Activation of complement system
neutrophils release ROS that destroy vessel wall
Type III hypersensitivity reaction
Antigen-antibody complex deposit in vascular wall
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C3a and C5A recruit neutrophils
Reactive Oxygen Species (ROS)
proteolytic enzymes
Genetic susceptibility