Please enable JavaScript.

Coggle requires JavaScript to display documents.

Red Cell Disorders - Coggle Diagram

- - - - thallassemia- genetic disorder may also caused reduced RBC and haematorcrit (one gene deletion) or uterine death (deletion in both aa and b genes)
        
        iron deficiency- microcytic low iron levels less than 80fL MCV
        
        sickle cell- abnormal Hb forming insoluble crystals @ low O2 sickle-shape
        
        haemolytic- red blood cells destroyed faster than bone marrow can replace them --> shortage
        
        renal- complication in chronic kidney disease normocytic anaemia
        
        iron + EPO
        
        pernicious - due to autoimmune disease lack of intrinsic factor for absorbing VB12
        
        1 more item...
        
        aquired- haemolytic transfusion reaction, malaria, drug-induced
        
        blockage in microcirculation
        
        genetic, single nucleotide polymorphism, amino acid substitution valine for glutamic acid
        
        reduced input in diet/stomach removal
        
        causes
        
        excessive bleeding- menses, NSAIDs, ulcers, colon cancer
        
        pregnancy- increased demand
        
        complications dilution / iron deficiency due to increased circulatory needs of placenta- normocytic as pregnancy increase MCV but iron deficiency decreases MCV
        
        oral FeSO4, + folic acid (prophylaxis in pregnancy), iron transfusion
        
        a & B based on how many a and B globins are missing
      - tiredness, decreased resistance to infection and increased bleeding
        
        bone marrow transplant, immunosuppressants - prevent immune destruction of stem cells colony stimulating factors- increase WBC count
      - mostly aquired (virally, radiation, drugs) cytotoxic anti-cancer drugs, chloramphenicol, sulfonamides, insecticides
  - - - methotrexate action can be treated with folate