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siRNA (small interfering RNA) technology - Coggle Diagram
siRNA (small interfering RNA) technology
Sequence Design
Target gene selection
mRNA region selection
Off-target minimization
GC content optimization
siRNA Structure
21–23 nucleotide duplex
3’ overhangs
Sense vs antisense strand design
Chemical Modifications
2’-O-methyl (2’-OMe)
2’-fluoro (2’-F)
Locked nucleic acids (LNA)
Phosphorothioate backbone
Cholesterol conjugation
Stability Optimization
Nuclease resistance
Serum stability
Reduced immune activation
RNA Interference Pathway
Cellular Uptake
RISC Loading
Strand Selection
mRNA Cleavage
Delivery Systems
Lipid-Based Delivery
Polymer-Based Delivery
Conjugate-Based Delivery
Viral Delivery
Physical Methods
Targeting Strategies
Passive Targeting
Enhanced permeability (tumor targeting)
Active Targeting
Ligand-receptor targeting
Antibody-mediated targeting
Tissue-Specific Targeting
Liver (GalNAc)
CNS delivery
Ocular delivery
Pulmonary delivery
Applications
Therapeutic Applications
Genetic Disorders
Oncology
Infectious Diseases
Cardiometabolic Diseases
Neurological Disorders
Agriculture
Pest Control
Disease Resistance in Plants
Herbicide Development
Trait Enhancement