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Atherosclerosis & Theranostic System - Coggle Diagram
Atherosclerosis & Theranostic System
Atherosclerosis Progression
LDL enters vessel wall
Oxidation to oxLDL
Macrophages engulf oxLDL
Foam cell formation
Increased MMPs, ROS, Cytokines
Collagen breakdown
Fibrous cap weakening
CD47 overexpression
Inhibits phagocytosis
Foam cell accumulation
Necrotic core formation
Plaque growth
Plaque instability
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Targeted Theranostic Treatment
Nanoagent injection
Circulation in bloodstream
Targeting mechanisms
Macrophage membrane (inflamed endothelium)
CLIKKPF peptide (binds PS)
Accumulation in plaque
High ROS environment
Polymer degradation (thioketal cleavage)
Atorvastatin release
CD47 downregulation
Efferocytosis increased
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