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Parkinson's Disease - Coggle Diagram
Parkinson's Disease
Treatments
Surgical interventions
Deep Brain Stimulation (DBS)
Supportive therapies
Physical therapy
Speech therapy
Occupational therapy
Medications
Dopamine agonists
Levodopa (L-DOPA)
Causes
Genetic factors
Mutations in LRRK2, PARKIN genes
Environmental factors
Pesticides, toxins
Biological mechanisms
Accumulation of alpha-synuclein protein
Loss of dopamine-producing neurons in substantia nigra
Research Methods
Machine learning for early diagnosis
Analysis of movement data, voice, handwriting
Statistical analysis of clinical trials
Big data and genetics (biostatistics)
Brain network modeling (graph theory)
Mathematical modeling of dopamine dynamics
Simulation of deep brain stimulation effects (differential equations)
Symptoms
Motor Symptoms
Rigidity
Postural instability
Bradykinesia
Tremor
Non-Motor Symptoms
Sleep disorders
Loss of smell
Depression and anxiety
Cognitive decline