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Patterns of Hepatic injury, Focal necrosis (part of liver), Diffuse…
Patterns of Hepatic injury
Degenerative changes
hydropic changes (ballooning)
fatty change
Necrosis
Single cell death (councilman body)
: involves only 1 hepatocyte
Lytic, dropout necrosis
: group of hepatocytes in middle of lobule
Confluent necrosis
: involves multiple lobules
Centrilobular necrosis
: around central vein
Bridging necrosis
: P-P, C-C, P-C
Piece meal necrosis
: inflammatory cells from portal tract result in destruction of hepatocytes -->
interface hepatitis
Massive necrosis
: most of liv
Submassive necrosis
: entire lobule
Inflammation
Hepatitis
portal tracts
porto-lobular interface
lobule
cholangitis (biliary tree)
Fibrosis
portal
bridging fibbrosis
peri-central fibrosis (around central vein)
Focal necrosis (part of liver)
Diffuse necrosis