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Serotonin Syndrome, Clinical Manifestations, Underlying Pathophysiology,…

- - - - Serotonin has a broad range of regulatory roles across the body, excessive serotonin causes dysfunction across multiple important systems, including unconscious ones
        
        In the cardiovascular system, serotonin helps to regulate heart rate, vascular changes (constriction/dilation), as well as aspects of platelet aggregation
        
        In the gastrointestinal tract, serotonin has broad roles across the entire system from gastric emptying and peristalsis to secretion regulation
        
        The respiratory system also involves serotonin, it plays into signaling pathways that control beathing
        
        Within the CNS itself, serotonin has broad behavioral roles as well as regulating the circadian rhythm, body temp, and the berebellum.
        
        There are more impacted systems, and broadly we can state that if it has 5-HT receptors, excess serotonin can bring impacts.
        
        Excessive serotonin within the body results in hyperactivity across the cardiovascular system, neuromuscular system, respiratory system, the autonomic nervous system, and cognitive impairments, reflecting the key 3 manifestations of ANS hyperactivity, cognitive alterations, and neuromuscular hyperactivity.