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Systemic Lupus Erythematosus (SLE), Deposits in - Coggle Diagram
Systemic Lupus Erythematosus (SLE)
Immune Dysfunction
Immune complex deposition
Complement activation
Leads to consumption of
Immune complex formation
Inflammation
Tissue damage
Loss of self-tolerance
Autoantibody production (ANA, anti-dsDNA)
Renal involvement (Lupus Nephritis)
Immune complex deposition identified in glomeruli
Protein leakage
Decreased oncotic pressure
Edema
Proteinuria
Increased permeability
Glomerular inflammation
Decreased filtration
Activation of RAAS
Hypertension
Increased creatinine
Hematologic involvement
Autoantibodies strike RBCs
RBC destruction
Targets
Anemia
Fatigue
Autoantibodies strike platelets
Thrombocytopenia
Bleeding risk
Skin and joint involvement
Immune complex deposition in the skin
Malar rash
Inflammation
Immune complex deposition in joints
Joint pain
Joint stiffness
Synovial inflammation
Diagnostics
Autoantibody production
Positive Anti-dsDNA
Positive ANA
Results in
Kidney damage
RBC casts
Elevated Creatinine
Proteinuria
Complement consumption
Low C3
Low C4
Treatment
Corticosteroids
Reduce inflammation
Decrease tissue damage
Suppress immune system
Suppresses
Reduces
Immunosuppressants
Reduce autoantibody production
Prevent immune complex formation
Reduces
Prevents
Anti-hypertensives
Reduce BP
Protect kidney function
Reduces
Deposits in
Deposits in
Deposits in