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Movement Disorder Drugs - Coggle Diagram

- - - - stimulating dopamine release and/or inhibiting its reuptake into neurons
    - - Livedo reticularis
        
        dilation of capillary blood vessels and stagnation of blood within these vessels causes mottled discoloration of the skin
      - Overdose can cause acute toxic psychosis
- - - - entacapone
      - and tolcapone
        
        also inhibits COMT in the CNS and blocks the conversion of dopamine to 3-methoxytryptamine
        
        Tolcapone has potential hepatotoxicity
  - - - inhibits MOA-B; since conversion of dopamine to DOPAL is accompanied by the production of hydrogen peroxide, treatment reduces reactive oxygen species and has been reported to block progressive neurodegeneration
      - usually administered w/ Leva-dopa
- - - - non-selective dopamine receptor agonist
    - - e: restlessness, depression, irritability, insomnia, agitation, excitement, hallucinations and confusion
      - overdose: acute toxic psychosis