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Antibiotic (?), Autoimmune - Coggle Diagram
Antibiotic (?)
Autoimmune
Immune system activation
Risk factors- female (estrogen)
IgM bind to RBC surface =marking for destruction
Complement pathways(C1q) -> C3b
Destruction by hepatic macrophage with C3b receptor
⬆️ HEMOLISIS = warm AIHA (gradual onset @ 37C)
Unconjugated bilirubin ⬆️
Hiperbilirubinemia (Pre hepatic jaundice)
RBC functional ⬇️ normal Hb⬇️
Anemia
Dyspnea ( O2 transport ⬇️)
Physical activity intolerance
Pallor
renal hipoxia
more EPO
Reticulocyte ⬆️ (bone marrow compensation to faster hemolysis)
1 more item...
Increase in LDH
Decrease Haptoglobin
Phagocyte by spleen Macrophage with fcy receptor
Removal of membrane before destruction continue in spleen
Spleenomegaly
nyeri tumpul LUQ
spherocyte finding
RDW increase
DAT +