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EM Sepsis - Coggle Diagram
EM Sepsis
Presentation
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Temperature
Hypothalmus
Cytokines released during sepsis causes hypothalamus to induce change in basal temperature
Immunocompromised / older pt may not have adequate immune response to produce fever
HR
Heart rate increases and systolic pressure can call
Due to tissue hypoperfusion or excess release of Nitric oxide by cells during sepsis leading to vasodilation
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Definition
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Septic Shock
Subset of sepsis in which there are profound circulatory, cellular and metabolic abnormalities which are associated with greater risk of mortality than sepsis alone
Patients with septic shock can be clinically identified by a vasopressor requirement to maintain a MAP of 65 or greater and serum lactate level greater than 2 mmo/L in the absence of hypovolaemia
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Causes
- bacteria
- Viruses
- Fungi
- Parasites
Pathophysiology
- Pathoge
- Into bloodstream
- Immune response and cytokine release
- Vasodilation, leaky capillaries, abnormal blood lotting
- Low BP and clotting impaires blood flow - organ dysfunction (sepsis
- Organ dysfunction results in cardio-pulmonary failure and drop in blood pressure that requires vassopressors / inotropes to maintain MAP above 65 (septic shock)
- Death
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