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BPC-157 - Coggle Diagram
BPC-157
Conclusion
The peptide induced fast healing
Benefits lasted for extended periods
Low dosages needed
Could be utilized for human benefit
More research needed to be done
What is it?
A peptide that can be
found in human gastric juices
Long name:
Gastric pentadecapeptide BPC 157
15 Amino acid chain
Introduction
Other peptide injections
did not provide tendon healing
Only provided undesirable
scar tissue
Transforming growth factor
(TGF)-b was the only exception
Carrier molecule needed
This was done with local
injections at the site of injury
It is possible BPC 157
does not need local injection
or a carrier molecule
Research was done on
torn tendons in rats
Potential positive outcomes
Wound healing
Entire tendon healing
Tendons have poor blood supply and therefore poor healing. This can be achieved in those conditions
Maintained healing afterwards
Can be done with or without
other growth factors
Results
Biomechanical recovery
Muscle strength increased
compared to control groups
Functional recovery
Quicker ability to walk again
Motor function returned
Less stiffness post-surgery
Appearance
Microscopic
Muscle fibers bridged
gap instead of scar tissue
Increased biological marker "desmin"
Desmin is a marker used
to indicate muscle regeneration
Macroscopic
Physical bridge built
over transected cut
Significantly
less atrophy
Methods & Materials
Used male Wistar rats
Suffered from complete
transection of quadricep muscle
Administration of
BPC 157 peptide
Derived from human gastric juices
Given once daily
Administered intraperitoneally
Given 30 minutes
after injury
Then for 72 days
For systemic effect