Please enable JavaScript.
Coggle requires JavaScript to display documents.
Types of Hormonal & Metabolic Dysfunction - Coggle Diagram
Types of Hormonal & Metabolic Dysfunction
Hormone
Excess
Definition
Overproduction of hormone
Excessive stimulation of target tissues
Diagnostics
↑ hormone levels
↓ feedback hormones
Causes
Tumors
Hyperplasia
Excess replacement therapy
Clinical Manifestations
Symptoms of overstimulation
hyperthyroidism → weight loss, tachycardia
Treatment
Hormone inhibitors
Surgery
Radiation
Dose adjustment
*
linked to Altered Clearance (excess may also result from ↓ breakdown)
Hormone Deficiency
:
Inadequate hormone production
Causes
Gland destruction
Autoimmune disease
Congenital absence
Clinical Manifestations
Symptoms of under-stimulation
Example: hypothyroidism → fatigue, weight gain
Diagnostics
↓ hormone levels
↑ stimulating hormones (loss of feedback)
Treatment
Hormone replacement
Treat underlying cause
Altered Hormone Secretion:
Abnormal
timing or pattern of hormone release
Causes
Pituitary dysfunction
Disrupted feedback loops
Clinical Manifestations
Inconsistent symptoms
Fluctuating hormone effects
treatment
Treat pituitary cause
Regulate secretion patterns
Linked to Hormone Excess or Deficiency
Altered Hormone Transport
Definition
Hormone produced normally
Impaired delivery to target tissues
Causes
Binding protein abnormalities
Liver disease
Clinical Manifestations
Reduced hormone availability
Mixed lab findings
Diagnostics
Normal total hormone
Abnormal free hormone levels
Treatment
Address binding issues
Treat underlying condition
Altered Hormone Receptor or Post-Receptor Response
: Target cells do not respond normally
Causes
Receptor defects
Post-receptor signaling problems
linked to Metabolic Disorders (diabetes, metabolic syndrome)
Clinical Manifestations
Hormone present but ineffective
Example: insulin resistance
Diagnostics
Normal or ↑ hormone levels
Poor physiologic response
Treatment
Improve receptor sensitivity
Lifestyle changes
Medications
Altered Hormone Clearance:
Impaired breakdown or removal of hormone
Causes
Liver dysfunction
Kidney disease
Clinical Manifestations
Prolonged hormone effects
Symptoms of hormone excess
Diagnostics
↑ hormone levels
Normal production rates
Treatment
Treat organ dysfunction
Adjust medication doses
Linked to: Hormone Excess