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special pharma 21 - 40, 31 (32), 36 (37), Diuretics, non opioid
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Loop
:check: Ac pulm. edema, HF, Renal failure, HyperCa, :green_cross: Hypokalemia, Ototoxicity, Dehydration
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Osmotic
Mannitol :check: Cerebral edema, Acute glaucoma
K⁺ sparing
B. Na⁺ channel blockers - Amiloride, Triamterene
A. Aldosterone antagonists - Spironolactone, Eplerenone
M: ↓ K⁺ loss, ↓ Aldosterone action
:check: HF, Hyperaldos, Prevent hypoK :green_cross: HyperK, gynecomastia (spironolactone)
Imidazo
ago
Moxonidine / :check: HTN / :green_apple:: less sedation, dry mouth than α₂
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Statin : Atorvastatin, Rosuvastatin, Simvastatin
: ↓ LDL by 🚫 HMG‑CoA reduc - :green_cross:Myopathy, ↑ liver enz
25
ADHD: Methylphenidate ⭐, Amphetamines, Atomoxetine (non‑stimulant)
---------- ↑ Dopamine & NE, Inhibit reuptake / :green_cross: isomnia, appetite supp, GR, Addiction
Nootropics : piracetam, Citicoline : improve cog
--------------- ↑ Cerebral blood flow, Neuroprotective effect
Narcolepsy : Modafinil ⭐, Amphetamines
---------------- inhib Dopamine re-uptake
Dementia
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NMDA rec Antagonist : :check: for sever / Memantine :small_orange_diamond: inhib NMDA glu rec, ↓ Excitotoxic neuronal damage
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Niacin : ↑ HDL, ↓ TG :green_cross:flushing, hepatotox, hyperglycemia
PCSK9 :forbidden:: Alirocumab, Evolocumab
: ↓LDL by prevent LDL rec deg
Bile acid seq :Cholestyramine, Colestipol
: ↓LDL by bind bile acid in intes :green_cross:GI upset, ↑ TAG
Fibrate : Fenofibrate, Gemfibrozil : :star2: PPAR-‑α, ↑ Lipopr lipase ↓ TAG :green_cross:Myopathy, Gallstone
other
Digoxin : ↑ Vagal tone, in AF w/ HF
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II : β - Propanolol, Atenolol, Metoprolol : ↓ cAMP → ↓ SA node automaticity → ↓ AV conduction
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α₂
ago
↓NE release → ↓Symp tone / :green_cross: Sedation, Dry mouth, Rebound HTN
Clonidine / :check: HTN, Preg‑induced HTN (methyldopa)
α₁
antag
Prazosin / :check: HTN, B prosta hyperpla (BPH) / :green_cross: First‑dose hypotension, Dizziness
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Ptg
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↑ cAMP in vas smooth m., Vd, Inhibit pl agg
PDE inhib
5 Sildenafil : M: ↑ cGMP → Vd / :check: Erectile dysfunction, Pulm HTN / ⚠️C/I: + nitrates → severe hypotension
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Thiazide
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:check: 📌 first‑line drugs for HTN, Mild HF, Nephrogenic diabetes insipidus :green_cross: HypoK, Hypergly, Hyperuric
Carbonic anhyd inhib
Acetazolamide :check: Glaucoma, Acute mountain sickness, Metabolic alkalosis
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29 uric acid meta
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Xanthine oxidase :forbidden: : Allopurinol ⭐, Febuxostat :small_orange_diamond: ↓ urate synthesis
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