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Immunodeficiency - Coggle Diagram

- - - - Usually azithromycin
        Doxycycline
        Septrin
    - - Less often - in HSV enceph, Tcell defect, recurrent shingles
    - - If neutrophil defect, recurrent fungal infx, chronic mucocutanaeous candiddiasis
- - - - CVID
- - - - Prompt tx with abx - 2 w
        +/- prophylactic abx
        =/- vax flu and covid
    - - Resp
        Bowl
        AI cytopaenias
        Increased lymphoma risk - monitor and interval CT imaging
- - - - Anatomical
        
        Splenectomy
        
        Emergency traumatic
        
        Eletive : ITP, haemolytic anaemic, debulking abdo cancer, splenic MZL
        
        Congenital abscence
      - Functional
        
        Sickel cells
  - - - Encapsulated bacterias
        Men b
        Men ACWY
        Strep pneumo
        HiB
        Annual and
      - Emergency: Start 2 weeks post op
        Elective : 2 weeks prior to
    - - Penicillin
        Arythromycin if allergic
- - - - Low risk
        
        Highly selective MAbs
        
        Vedolizumab
        Omalizumab
      - Moderate
        
        MAbx inhibiting cells involved in infection related immunity
        
        Anti b cell therapies . Anti CD20 Mabs
        JAK inhib
        TND alpha inhibit
      - High
        
        MAbs suppressing multiple arms
        
        Alemtuzumab?
    - - Screen laten infection prior
        
        IGRA
        Hep B
        Hep C
        HIV
        
        Maybe:
        CMV
        EBV
        HSV
        VZV
        
        Positive IGRA / Hep B not a complete contraindication
      - Vaccinations prior
        
        Flu
        Covid
        Pneumovax
        Shringrix if VZV ab neg
        Live vaz need to ve avoided in setting of most biologicals
      - Patient education
        
        Consider holding meds if active infx