:star: De Novo Lipogenesis: synthesis of fatty acids from glucose/ acetyl-CoA
Pathway - glucose --> acetyl-CoA, ACC (acetyl-CoA carboxylase, rate limiting), converts acetyl-CoA to malonyl-CoA, FAS (fatty acid synthase, builds fatty acid chain), final product palmitate (16 Cs, 0 double bonds)
Regulation:
Activated by - insulin, glucose, SREBP-1c
Inhibited by - glucagon, AMPK, fatty acids