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Stage 4 - Coggle Diagram

- - - - Clear cell histology
        
        Pembrolizumab
        
        Active surveillance
      - Non clear cell histology
        
        Surveillance
  - - - Tissue sampling
        
        cabozantinib+nivolumab
        
        ipilimumab +nivolumab
        
        lenvatinib+pemb
        
        Axitinib+pembrolizumab
    - - Cabozantinib
      - Cabozantinib+ nivolumab
      - lenvatinib + pembolizumab
- - - - Axitinib+pembrolizumab
      - cabozantinib+nivolumab
      - ipilimumab +nivolumab
      - lenvatinib+pemb
  - - - Tissue sampling
        
        cabozantinib+nivolumab
        
        ipilimumab +nivolumab
        
        lenvatinib+pemb
        
        Axitinib+pembrolizumab
    - - Cabozantinib
      - Cabozantinib+ nivolumab
      - lenvatinib + pembolizumab