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immune system - Coggle Diagram
immune system
concept of immunity
susceptibility-lack of resistance to disease
immunity-ability to ward off disease
innate immunity- defenses against any pathogen; immediate & non-specific
adaptive immunity- resistance to a specific pathogen; learned & memory based
Innate Immunity-Second Line of Defense
Phagocytic WBCs
Neurtrophils
Macrophages
Dendritic cells
Inflammation--redness, heat, swelling
Fever-slows pathogens growth by raising body temp
Complement system
Opsonization
Inflammation
Chemotaxis
Cell lysis
Adaptive Immunity Overview
Specific
Humoral& cell mediated responses
B cells- humoral (antibodies)
T cells- cell-mediated
Innate Immunity- First Line of Defense
Physical Barriers
Intact skin
Muscous membranes
Normal microbiota
Mechanical Deffense
Tears
nature flow
Chemical Defenses
Antimicrobial peptides
lysozyme
Lactoferrin
Cytokines
Interlleikinds-coordinate & modulate immune functions
Chemokines-recruit leukocytes/WBCs to infection site
Interferons-alert cells to viral infection; activate NK cells
Cellular Defenses
WBCs(Franulocytes
Neutrophils
Eosinophis
Basophils
Monocytes-mature into macrophages
Lymphocytes
B cells- produce anitbodies
T cells
B cells
Recognize antigens
Differentiate into plasma cells- secrete antibodies
Some become memory cells- long-term immunity
T cells
T helper cells
Express CD4
Bind antigens on MHC 2
Cytotoxic T cells
Express CD8
Kill virus- infected or ceancer cells
Antibodies& Antigens
Antigens-tigger an immune response
Antibodies (immunoglobulins)
Neutralization
Plasma Protein Mediators
Acute-phase proteins
C-reactive protein-binds microbial structures
Ferritin-binds % swquesters iron
Transferrin-binds & transports iron
Mannose-biding lectin- activates complement cascade