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L10 Human Aging - Coggle Diagram
L10 Human Aging
Mitochondrial decay theory
oxidative damage on mtDNA
No histone protein protection on mtDNA
No repair systems
Inner mitochondrial membrane has oxygen & hydroxyl free radicals
mtDNA fragments insertion
Pericentromeric region
Affects nearby centromere
Causes chromosome missegregation during mitosis
Aneuploidy
Corrupt structural genes
Stops cell division (mitotic decline)
Cell senescence
Release senescence associated secretory phenotype (SASP) to surrounding cells
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Modifies regulatory sequences
Genomic instability
nDNA (induced by mitROSp)
Shorten longevity
Short lifespan
More mtROS prod
More unsaturated fatty acids in tissue membranes
Eating less food (dietary restrictions)
Challenges
Understanding interconnections between hallmarks
Identifying drugs that improve health (Without side effects)
Research advancements
Identifying genetic components
SNP regional clusters (HapMap)
No explanation for what genes cause age-related diseases
Cause
Impaired functions
Signaling defects
Energy insufficiency
Apoptosis