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Hypothalamus and Pituitary Gland, Feedback, Development, Anterior and…

- - - - peptide hormone secreted from hypothalamus
      - Binds to GPCR in anterior and stimulates GH release
      - Ghrelin produced by stomach stimulates GHRH secretion
    - - Peptide Hormone released in anterior
      - Binds receptor in liver (cytokine receptor)
      - signaling cascade triggers production of IGF in liver
- - - - Pars tuberalis
        
        part that wraps around posterior pituitary
      - Pars intermedia
        
        Separates anterior and posterior
        
        Some species have, some don't
      - Pars distalis
        
        Lobe part
    - - Bone that protects pituitary gland
    - - continuation of hypothalamus
      - Infundibular stalk
        
        Connecting tube
      - Pars nervosa
        
        lobe part
- - - - Somatotrophs
      - Lactotrophs
      - Gonadotrophs
      - Thyrotrophs
      - Corticotrophs
    - - Melanotrophs
    - - SOX2 and SOX9
  - - - Short axons
    - - Released in primary capillaries of Median eminence
    - - Hypothalamic-hypophysial portal vessels
- - - - stored in secretory vesicles until release
- - - - Reproductive effects
      - Androgens, estrogens, progestins
  - - - Growth Effects
      - IGF-1
  - - - Thyroid hormones
      - Metabolism effects
  - - - Milk Production
  - - - melanin
      - Skin/fur pigmentation
  - - - Glucocorticoids (steroid hormones)
      - Inflammation and metabolism