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Single-Cell Proteomics - Coggle Diagram

- - - - Labeling with TMT (in case of DDA)
        
        Pooling of the labelled proteome from a cell with that from other cells to meet the LOD
        
        LC/MS
        
        Data analysis
        
        Carrier cells (labelled with a specific TMT channel) can also be added to increase the detectable peptide fragments
        
        It's also possible to pursue label-free approaches, but in that case we have to run each LC/MS in parallel
        
        Non-isobaric tags (for DIA) are also available
      - All of the volumes from the used solutions must be very low