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Drugs and the Kidney - Coggle Diagram
Drugs and the Kidney
MOA SGLT2 inhibitors
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Abiity to lower blood glucose and HBa1c levels is limited by the filtered load od glucose and osmoting
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ACEi/ARBS
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Initiate with lower dose
- risk of hyperkalaemia
- Some have lowe mx doses - perido
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Antimicrobials
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Tacrolimus
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Lots of interactions
Avoid erythro, clarithro, use azithroycin
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Metformin
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- Can use safe in normal GFR and stage 3A
- Caution in CKD stage 3b -reduce dose
- Avoid Stage 4
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HIV Retroviral Rx
Indinavir, lopinavir, atazanavir
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Sick Day Medication List
If a pt with CKD is unable to maintain adequate fluid intake / excess fluid lossess during an illness - advise potentially nephrotoxic or renally excreted drugs should be held 24-48hr until pt has recovered
SADMAN
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Diuretics, direct renin inhibitors - particullarly Loop
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NSAIDs
Risk Factos
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- Volume depletion from diuretics, vomiting, diarrhoea
- HF, nephrotic syndrome, cirrhosis
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