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Intro + biopsy sampling - Coggle Diagram
Intro + biopsy sampling
Primary lesions develop as a direct consequence of disease process
Secondary lesions evolve from primary lesion or are caused by the patient (self trauma)
Inflammation = response of living tissue to injury
Patterns of inflammation
perivascular = around blood vessels
diffuse/ interstitial = in tissues surrounding alveoli
nodular = lump/nodule forms as a result of inflammation
panniculitis= in subcutaneous fat
interface= at the junction between epidermis + dermis
folliculitis= hair follicle
When to biopsy
suspect neoplasia
persistent ulceration
unusual/severe signs
no response to rational therapy
no diagnosis from methodical investigation
disease only confirmed by histopath
When NOT to biopsy
diagnosis by history + clinical signs
diagnosis by basic microscopical tests
uncomplicated allergic phenotype
trail therapy less problematic/less expensive
Skin biopsy
do not surgically prepare the site as you may remove diagnostic features
10% neutral buffered formalin
punch biopsies
routine with 6 or 8mm punch
4mm if footpads/ nasal planum
8mm for large lesions
excisional biopsies
lesions of panniculus
vesicles/ bullae
larger lesions e.g. nodules
needs to be selective: case type, lesion type, sample method, lap