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Kidney & Urinary Tract Embryo, Intermediate Mesoderm, Pronephros,…
Kidney & Urinary Tract
Embryo
Kidney
Urinary System
Upper
(Kidneys, ureter, upper bladder)
Intermediate mesoderm
Lower
(lower bladder, urethra)
Endoderm (Lining in bladder/urethra) &
Splanchnic mesoderm (connective tissue/smooth muscle)
Intermediate Mesoderm
Pronephros
(1: tubules and a longitudinal duct)
Mesonephros
2:
(pronephros duct & wolffian duct
-->tubules--glomerulus (branches dorsal aorta b/l
-->Bowman's capsule
Joins
Colaca
Urogenital sinus (anteriorly)
MALES: Prostatic & Membranous urethra
OR
FEMALES: Entire Urethrea
(PELVIC PART)
Males: Spongy Urethra
(PAHLLIC part)
Urinary bladder
(cranial part)
Connected to
Allantois
Urachus
1 more item...
Anal canal (posteriorly)
Proliferation Urorectal septum
Perineal body
Gives rise to ureteric bud/
collecting duct system
Primitive Renal Pelvis
(Dilated bud)
Major calyces
Minor calyces
Ureter
(stalk of bud)
PENETRATES
(through elongation)
Signaling FACTORS
Continued Branching
Nephrons
Collecting tubules (form renal vesicles)
in metanephric tissue caps
S-shaped excretory tubules
Glomeruli (surrounded by Bowman's capsule)
open connection is formed
Excretory tubules continues forming (PCT, LH, DCT)
Gonadal structures
Metanephros
3: Adult Kidney
Nephrogenic cord
gives rise to
Metanephric msedoerm
Metanephric blastema
WTN1 PRODUCED
Ascend from s1-s2 to T12-L3
Switch from Common Illiac to Abdominal aorta
Pronephros, Mesonephros
OVERLAP
Urogenital ridges
Nephrogenic cord
(4th weeks form pronephric duct
pronephric tubules
extends into cloaca)
Wilm's Tumor
WAGR Syndrome
(LOSS OF WT1)
Renal Agenesis
Fail to form/induce
metanephric blastema
MOST COMMON
Duplicated Ureter/Pelvis:
Splitting of bud before
Penetration
Renal Hypoplasia:
Premature cessation or error
Pelvic kidney &
Horseshoe Kidney
Urachal Anomalies
(Lumen of allantois is not obliterated
Urachal fistula)
Exstrophy of Bladder/Cloaca
(epispadias)
Accessory Renal aa./vv.
Caudal vessels fail to regress as they ascend
5th week
Weeks 4-7