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Glioblastoma - Coggle Diagram
Glioblastoma
Molecular, Genetic & Cell Cycle Control
HMW use gene therapy after surgery
:fire: HMW targets the cell cycle
HMW target the natural way cells die
HMW Induce apoptosis
HMW Introduce genetic mutations
HMW Prevent protein translation
HMW Prevent gene transcription
HMW target Telelomes of residual cancer cells
HMW Decrease telomere length
Physical and Mechanical Ablation
HMW laser away residual cancer cells
HMW use sonar waves to target residual cells
HMW Microbubble explosion
HMW freeze away residual cancer cells
HMW Mechanically Lyse
HMW Create sufficient heat to denature proteins
HMW remove/cut out residual cancer cells
:fire: HMW use wave therapy on tumor cells
Energy-Based & Targeted Cell Disruption Methods
Energy-Based Ablation (Non-Invasive)
Photothermal Therapy
Heat waves to burn cancer cells :fire:
Photodynamic Therapy
:fire: Phototherapy to create Free radicals
Focused Thermal/Acoustic Techniques
Heat up inside of cell so they pop
Sonar therapy (Focused Ultrasound) :fire:
Infrared Therapy
:fire: Infrared therapy
Targeting Methods & Cellular Disruption
Targeting Residual Cells
Photo bio marker to target residual cells
Disruption Mechanisms (Cellular/Sub-cellular)
Disrupt cell wall :fire:
Disrupt organelle function
Target the way the cell moves
Electromagnetic & Neural Targeting
Target neuronal electrical waves
Low Electrical waves
Magnetic waves therapy :fire:
Therapeutic Energy Types (Classification)
Types of waves:
Heat
Light (UV, IR)
Sound (focused ultrasound)
Electromagnetic
Immunotherapy & Biological Agents
HMW Create an immune response targeting cancer cells
HMW make macrophages eat the residual cancer cells
HMW Induce macrophage endocytosis
HMW Make a cancer specific opsonin
HMW Utilize complement activation to kill cancer cells
HMW Use CAR-T
HMW use bacteria to kill residual cancer cells
HMW Create a virus that targets cancer cells
Metabolic & Microenvironment Control
HMW target perivascular spaces
HMW target the basement membrane/ECM
HMW Starve the cell
:fire: HMW Prevent oxidative metabolism
HMW Cause oxidative injury
HMW Reduce blood vessel supply
HMW Create significant pH shifts
HMW Cause the cell to produce intracellular toxins
Membrane & Transport Disruption
HMW Destroy the cellular membrane
HMW Electroporate the cell membrane
HMW Electroporate the nucleus
HMW Disrupt normal ion transporters
:fire: HMW Concentrate toxic levels of ions
HMW Create osmotic pressure difference
HMW change the material properties of the cancer cells?
Spatial Manipulation, Visualization & Safety
HMW visualize residual cancer cells
HMW protect all of the other cells
HMW make it safe to remove more brain tissue
HMW force residual cancer cells to the surface
HMW Force/push them out
HMW Lure/pull them to the surface
Pharmaceutical & Chemical Delivery
HMW use a drug delivering stent
HMW deliver targeted currently available chemotherapy
HMW deliver chemo specifically to the residual cancer cells
:fire: HMW Deliver chemotherapeutic locally
Drug Delivery Methods for Intracranial/Surgical Cavities
Implants & Devices
Internal Devices
VP shunt
:fire: Intracranial pump
Port to deliver chemo to cavity
Drug-Eluting Implants
Drug eluting implant left in cavity
Solid chemo implant to fill cavity
:fire: Drug delivery stent
Drug delivery sponge
Material-Based Delivery Systems (Gels, Pastes, Sponges)
Hydrogels & Pastes
Hydrogel
:fire: Chemo hydrogel to fill cavity
:fire: Chemo paste to coat surface area of cavity
Visualize margins and coat those areas with chemo gel
Biodegradable Sponges & Matrices
:fire:: Biodegradable sponge
Chemo soaked sponge to fill cavity
:fire:Chemo-coated fat
Intra-Cavity Coating & Filling Techniques
Liquid & Foam Fillers
Liquid chemo to fill cavity
Expanding foam chemo to fill cavity
Aerosolized Delivery
Cavity filled with aerosol of the drug
Aerosolized chemo to fill cavity
Positional/Flow-Assisted Delivery
Rotate head to fully coat inner cavity with chemo?
Non-Local & Advanced Concepts
Tissue Engineering / Autologous Implants
:fire: Implanting tissues from other bodyparts
Physiological Targeting
Use of venous sinus
:fire: HMW deliver drugs that freely travel through the supercell microtubule network