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Microbial Pathogenesis - Coggle Diagram
Microbial Pathogenesis
Definition
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Mechanisms of entry, spread, and interaction with host
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Portals of Entry & Exit
ENTRY: Skin, Inhalation, Ingestion, LD50/ID50 vary by portal, placenta
EXIT: Allow pathogen to leave host and infect new hosts (Ex. coughing, sneezing [respiratory])
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Invasion
Intracellular pathogens: Obligate or faculative, Entry via endocytosis, Effector proteins → membrane ruffling (salmonella, shigella), Surface proteins bind host receptors
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Virulence Factors
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Hyaluronidase → breaks hyaluronan, DNAse (S. aureus) → degrades extracellular DNA, Collagenase (C. perfringens) → breaks collagen & enables bloodstream entry
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Bacteremia, Viremia, Toxemia, Septicemia → septic shock (dangerously low BP)
Intracellular-targeting toxins (cholera, tetanus, botulinum, diptheria), Diptheria toxin → inhibits protein synthesis, Neurotoxins: botulinum & tetanus (A-B structure)