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thyroid drugs - Coggle Diagram
thyroid drugs
hyperthyroid drugs
anti thyroid drugs
thioamides
carbimazole
Inhibits TPO → inhibits iodination & coupling
takes 3 weeks to produce effect
found in breast milk & placenta
PTU
inhibits conversion of T4 → T3
AE: skin rash
I: preparation for surgery, DOC for pregnant woman
methimazole
Inhibits TPO → inhibits iodination & coupling
radioactive iodine
taken by NIS → damages thyroid glands
I: prevent thyroid crisis
Iodides
lugol & potassium
reduce vascularization from hyperplastic of thyroid gland
inhibits iodination
supportive treatments
propanolol
beta blocker
amiodaronea
anti arrhythmia effect
inhibits conversion of T4 to T3
hypothyroid drugs
synthetic drugs
levothyroxin (T4)
T1/2: 6-7 days
AE: hypermetabolic state
increase absorption by fasting
liothyronin (T3)