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ACLR思路/Hamstring graft, 半腱肌CSA為對側34%（6個月）、76%（12個月）、92%（24個月）, Estrogen…
ACLR思路/Hamstring graft
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實驗設計
Method
Population
Injuried, uninjuried, healthy control (3 group)
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- Estrogen can enhance tendon collagen synthesis rate
- Active young female athletes, physiological high concentration of estrogen may enhance the risk of injuries due to reduced fibrillar crosslinking and enhanced joint laxity
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- Testosterone: enhance tendon stiffness (tendon collagen turnover and collagen content)
- Testosterone reduced responsiveness to relaxin
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男女生Stiffness有差：Patella tendon, Achilles tendon
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Isokinetic muscle strength, EMG
Achilles tendon healing (ATH) remains an unanswered question in the field of sports medicine because it does not produce tissue with homology to the previously uninjured tissue. Oestrogen receptor β (ERβ) is involved in the injury and repair processes of tendons. Our previous study confirmed that ERβ plays a role in the early stage of ATH by affecting adipogenesis, but its role in extracellular matrix (ECM) remodelling is unknown.
Bian X, Liu T, Yang M, et al. The absence of oestrogen receptor beta disturbs collagen I type deposition during Achilles tendon healing by regulating the IRF5-CCL3 axis. J Cell Mol Med. 2020;24(17):9925-9935. doi:10.1111/jcmm.15592
