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Paracetamol (Acetaminophen) Poisoning - Coggle Diagram
Paracetamol (Acetaminophen) Poisoning
Mechanism
Paracetamol ----->NAPQI + cell proteins = kills liver cells
Treatment
Activated charcoal
Agents that increase glutathione e.g NAC
Antidote (NAC)
Liver transplant
Agents that increase conjugation reaction e.g methionine
Complications
Kidney failure, pancreatitis, hypoglycemia,lactic acidosis
Mechanism of NAC
Increases concentration of glutathione
Enhances sulfate conjugation of unmetabolised paracetamol
Dosage for us to say this is paracet poisoning (150mg/kg)
People at risk (those taking enzyme inducing drugs)
Carbamazepine
Alcohol
Primidone
Rifampicin
Carbon Monoxide Poisoning
Mechanism
Carbon Monoxide binds irreversibly with haemoglobin forming carboxyhemoglobin (which cannot transport oxygen).
Clinical Effects
Headache, Confusion, Convulsions, Shock, Respiratory system failure
Treatment
Hyperbaric oxygen therapy or 100% oxygen
Remove individual from exposure source and maintain respiration