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Respiratory Embryo, Bronchi and Lung Formation, Week 4, Week 5,…
Respiratory
Embryo
Endoderm
Lungs
Trachea
Epithelium of Larynx
Respiratory Glands
Bronchi
Splanchnic Mesoderm
Cartilages
Smooth muscle
Connective Tissues
Lung Bud (Respiratory Diverticulum)
Week 4 on ventral foregut wall
Tracheoesophageal septum
Esophagus
Laryngotracheal tube
Laryngeal Arches
IV
VI
Laryngeal Orifices
(trachea/foregut:
Primitive entrance to larynx
Larynx Growth and
APOPTOSIS -->
Recanalize Lumen
Tracjealis M develops
(decrease diamaeter-->
produtive cough)
Pericardioperitoneal canal
Primitive pleural cavities
Seperate Heart & Lungs
Bronchi and Lung Formation
Bronchial Buds (28 days)
Primary Bronchus (35 days)
Tertiary Bronchi (6 weeks)
LOBES DEFINEd (56 days)
Lung Maturation
Canalicular stage (16-26 weeks)
Type II Alveolar Epithelial
--> SURFACTANT @ Week 20 (better at 26 weeks)
Type I (alveolar epithelium)
Terminal sac stage (26 weeks - birth)
Primitive Alveoli
Pseudoglandular stage (5-16 weeks)
Alveolar stage (32 weeks -10 years)
Week 4
Week 5
Congenital Anomaly: FISTULA
GAS
Inability to drink milk
Week 10
Pathology
Laryngotracheoesophageal Cleft
OR
Atresia or Web
Week 11
Visceral Pleura derived splanchnic mesoderm
Parietal Pleura derived from somatic mesoderm