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Connective tissue - Coggle Diagram

- - - - Fibroblasts
        
        Principal cell, abundant
        
        Synthesis of fibers and ECM components
        
        Active/quite
        
        cell repair
      - Fibrocyte
        
        Smaller than active fibroblast
        
        Spindle shaped
        
        smaller, darker, elongated nucleus
        
        small amount rER
      - Active fibroblast
        
        Abundant, irregular branched cytoplasm
        
        nucleus: large, pale staining, ovoid
        
        Rich in rER
      - Myofibroblast
        
        Actin & myosin
        
        fibroblasts, smooth muscle
        
        wound closure ( contraction), healing
      - Macrophages
        
        Phagocytic cell
      - Mast cells
        
        Storage for chemical mediators
        
        Histamine
      - Adipose cells
        
        loose connective tissue
        
        nucleus is flattened & eccentric
    - - Lymphocytes
      - Plasma cells
        
        b-lymphocytes
        
        antibodies
        
        eccentric nucleus
        
        basophilic
      - Neutrophils
      - Eosinphils
      - Basophils
      - Monocytes
  - - - Collagen
        
        Most abundant protein
        
        Flexible, high tensile strength
        
        Type
        
        1
        
        skin, tendons, ligament, bone
        
        resistance to tensile stresses
        
        2
        
        Resistance to pressure
        
        Elastic cartilage (软骨）
        
        4
        
        basal lamina of basement membrane
      - Reticular
        
        From type 3 collagen
        
        Thin, branching
        
        abundant in liver, spleen, lymph node
        
        mesh-like pattern or network
      - Elastic
        
        Thinner than collagen
        
        prevent excessive stretching
        
        3 dimensional network with branching pattern
        
        Elastic arteries
    - - viscous, clear substance
      - high water content
      - fill up space between fiber and cell
      - lubricant & barrier
      - Components
        
        Glycosaminoglycans
        
        Proteoglycans
        
        Multi-adhesive Glycoproteins
- - - - below epithelia covering body surfaces
      - lining internal surface
    - - mast cells
      - fibroblasts
      - macrophages
      - collagen fibers
      - elastic fibers
  - - - Collagen bundles arranged parallel
      - fibroblast nuclei in rows
      - tendons, ligament
      - subtypes
        
        dense regular elastic connective tissue
        
        elastic fibers arranged in parallel
    - - abundance of fibers, few cells
      - thick collagen fibers in various direction
      - little ground substance
      - submucosa of hallow organ
      - reticular layer of dermis
- - - - Adult
    - - baby