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Microbial Pathogenesis - Coggle Diagram
Microbial Pathogenesis
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Types of Infection
Local Infection: confined to a small area EX: boil or abcess, staph a
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Virulence Factors
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Produced by individual pathogens determine the extent and severity of the disease that they may cause
Functions include: damage to host cells, protect against immune defenses, produce endotoxins and exotoxins
Toxins
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Endotoxin: lipopolysaccharide located in Gram (-) bacteria. Outer membrane of gram negative bacteria, more severe Lipid A
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Examples:
Neurotoxins: botulinum toxin, tetanus toxin (exotoxins), consists of light A subunit and a heavy protein chain B subunit
AB toxins: Diphtheria toxin inhibits protein synthesis, which stops protein elongation and kills the cell
Exoenzymes
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Examples
Hyaluronidase: breaks down polymer between cells- allows passage between cells that would otherwise be blocked
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Microbes In Bloodstream
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Septicemia: multiplying microbes in blood (may lead to septic shock) decrease in BP prevents the cells and organs from receiving enough oxygen and nutrients