Heroine
Heroine interfers with dopamine and unhubutiry neurotransmitters. It causes the release of inhibitory neurtoransmitters. Without inhibiton, dopamine can be released. It makes a person feel sedated and comfort because it binds ton parts of the brain responsible for transmitting pain signals, stress, and emotional attachment.
Ecstacy/MDMA
Ecstasy interferes with serotonin neurotransmitters. It mimics serotonin neurotransmitters and "confuses" serotonin trasnporters. Which causes it to start transporting serotonin out of the cell not in, The serotonin neurotransmitter bind again and again to serotonin receptors. Overstimulating it. It affects a persons mood because it releases areas serotonin and some dopamine. It also affects sleep, perception, appetite, and the reward pathway.
Marijuana
Marijuana interferes with inhibiotry neurtransmitters that are active in the synpase also dopamine neurotransmitters. Out bodies cannabiniod--anadnmide) bunds to cannabinoid receptors which turn off the release of inhibitory neurtransmitters. Without inhibiton, dopamine can be released. So dopamine receptors bind to dopamine neurotransmitters. THC mimns anandamide and binds to cannabinoid receptors, does the same thing, and dopeamine can go into the synpase. It makes people slow down, feel relaxed, and calm. It also removes short term memory.
Methamphetamine
Methamphatamine interfers with dopamine neurotransmitters. Once inside a cell, meth enters dopamine vesicles, forcing dopamine neurotransmitters/molecules out. Which are then pumped out of the cell and into synapse by dopamine transporters, wokring in rreverse. It binds to receptors and overstimulates cells. It makes people feel intense pleasure and exhilaration because it works directly on the brain's reward sytem.
Alcohol
Alchohol interferes with inhibitory nerotransmitters (GABA) and glutamate neurotransmitters (excitatory neurotransmitters). It makes GABA receptors even more inhibitory and binds to glutamate receptors. It can change people's impulse control, decsion making, and meory formation.
Cocaine
Cocaine interefers with dopamine neurotransmitters. It blocks dopamine transporters. So dopamine is trapped in the synpatic cleft. Dopamine neurotransmitters bind to dopamine receptors again and again. oversimulating the cell. It can make people figity, unable to sit still because it concentrates in the record pathway and parts if the brain controlling voluntary movrement.
LSD
LSD interfers with serotonin neurotransmitters. There are multiple types of serotonin receptors, LSD affects them differently. So it can either inhibit them or excite them. Giving it complex sensory effects. It excites the locus coeruleus which is responsible to feelings of wakefulness and evoking a startle respone to unexpected stimmulis.